Zaven Khachaturian on The amino-terminally truncated forms of amyloid beta-protein in brain macrophages in the ischemic lesions of Alzheimer's disease patients.

COMMENT This paper provides further evidence of a critical relationship between one of the important lesions associated with AD, A beta and inflamatory reactions in the AD brain. Important implications for developing treatments 0 zaven_khachaturian

Benjamin Wolozin on Functional gamma-secretase inhibitors reduce beta-amyloid peptide levels in brain.

COMMENT Important information on potential therapeutic approach to AD. 0 bwolozin

John Hardy on SNPing away at complex diseases: analysis of single-nucleotide polymorphisms around APOE in Alzheimer disease.

COMMENT Can we use SNP's and CHIP's to find genes which lead to complex diseases including late onset AD: this important paper illustrates it will be extraordinarily difficult or perhaps impossible. 0 J.Hardy

Paul Coleman on APLP2, a member of the Alzheimer precursor protein family, is required for correct genomic segregation in dividing mouse cells.

COMMENT Another paper relating mitotic mechanisms and AD. 0 Paul_Coleman

Hiroshi Mori on Cellular expression and proteolytic processing of presenilin proteins is developmentally regulated during neuronal differentiation.

COMMENT Comparison of Presenilin 1 and Presenilin 2 should be focused more in order to see the pathological etiology of AD. 0 mori

Hiroshi Mori on Estrogens stabilize mitochondrial function and protect neural cells against the pro-apoptotic action of mutant presenilin-1.

COMMENT Estrogen is expected to become a potent anti-aging or anti-AD treatment reagent for women and men. In the present study it is interesting to see a molecular mechanism of estrogen on PC12 cells acted upon by presenilin-1. 0 mori

Paul Coleman on The tau mutation (val337met) disrupts cytoskeletal networks of microtubules.

COMMENT An important paper that provides evidence for a mechanism of cellular dysfunction in FTDP-17. 0 Paul_Coleman

Hiroshi Mori on A nucleated assembly mechanism of Alzheimer paired helical filaments.

COMMENT The original theory for protein polymerization was established on actin molecule by Dr. Osawa. He said that the first nucleation step is the rate-determinant reaction while the second elongation step is relatively fast. This was applied to microtubule, am

Hiroshi Mori on GM1 ganglioside-bound amyloid beta-protein in Alzheimer's disease brain.

COMMENT Sugar is important because it helps to understand amyloid deposition mecahnism. It provides further evidence for that GM1 GANGLIOSIDE binds in vivo amyloid. 0 mori

Hiroshi Mori on Tau cleavage and dephosphorylation in cerebellar granule neurons undergoing apoptosis.

COMMENT Tau cleavage is one of post-translational modifications and occurs in human brains with or without AD. Its pathological function remains to be studied. 0 mori

Benjamin Wolozin on Biochemical characterization of the core structure of alpha-synuclein filaments.

COMMENT Understanding which elements represent the core of the filamentous synuclein is important because it suggests a region that can be targeted for studying aggregation. The results observed by Miake and colleagues are consistent with those observed by previo

Hiroshi Mori on Cis-acting human ApoE tissue expression element is associated with human pattern of intraneuronal ApoE in transgenic mice.

COMMENT They show that ApoE is also expresseed in neuron beside glial cells. It makes sense to how amyloid deposition is formed in the brain. 0 mori

Paul Coleman on Sulcal variability in the Alzheimer's brain: correlations with cognition.

COMMENT An interesting approach. It is not clear from the abstract how many sulcal measures there were and how many cognitive variables there were. It appears the number of variables may have exceeded the number of patients (10) by a wide margin. 0 Paul_Coleman

John Hardy on Simvastatin strongly reduces levels of Alzheimer's disease beta -amyloid peptides Abeta 42 and Abeta 40 in vitro and in vivo.

COMMENT Exciting data, which with animal data of Sparks and Refolo and colleagues, and clinical data from Wolozin and Jick and colleagues really puts cholesterol center stage in terms of APP metabolism. Is this the connection between ApoE and amyloid? 0 J.Hardy

Elliott Mufson on Endoproteolytic cleavage and proteasomal degradation of presenilin 2 in transfected cells.

COMMENT Interesting 0 emufson