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COMMUNITY NEWS 2024-05-10 Community News For decades, the U.S. Food and Drug Administration has taken a light touch to regulating diagnostic tests that use body fluids or tissues. Such assays, very much including cerebrospinal fluid and blood tests for Alzheimer’s disease, were ab
RESEARCH NEWS 2024-05-10 Research News For 30 years, APOE4 has ranked as the strongest genetic risk factor for Alzheimer’s disease, with two copies boosting the odds up to 15-fold. Now, scientists make the case that people with two APOE4 alleles are not merely at risk, but are de
RESEARCH NEWS 2024-05-09 Research News The Alzheimer’s risk gene phospholipase C-γ2 has been thought to act mainly in microglia. Now, in a May 1 preprint on bioRxiv, researchers led by Jean-Charles Lambert, Julie Dumont, and Julien Chapuis at Institut Pasteur de Lille, France, Mi
RESEARCH NEWS 2024-05-09 Research News Cross-sectional autopsy studies have suggested that, in Alzheimer’s disease, neurofibrillary tangles first appear in the locus coeruleus (LC) of the brainstem. Now, a longitudinal imaging study lends support to that theory. In the April 25 N
RESEARCH NEWS 2024-05-04 Research News Over the last few decades, evidence has emerged to peg the sortilin-related receptor, SORL1, as a risk factor for Alzheimer’s disease and even as the fourth gene for familial AD. SORL1 helps traffic amyloid precursor protein through the endo
RESEARCH NEWS 2024-05-03 Research News We all know that physical activity is good for us, and may even help stave off dementia. But what are the underlying molecular mechanisms? Understanding how exercise affects the entire body at the transcriptomic, proteomic, epigenetic, and m
RESEARCH NEWS 2024-05-03 Research News Scientists still have much to learn about how Aβ immunotherapy affects downstream processes in the brain. In the April 29 JAMA Neurology, researchers led by Eric McDade at Washington University School of Medicine, St. Louis, offer some hints
RESEARCH NEWS 2024-04-30 Research News Lipid droplets accumulate in microglia in mouse and cell models of amyloidosis but scientists are not sure why. Evidence suggests that Aβ helps create the glut, but now scientists led by Lingyan Shi and Xu Chen at the University of Californi
RESEARCH NEWS 2024-04-27 Research News C-terminal fragments of amyloid precursor protein have been blamed for endolysosomal dysfunction in Alzheimer’s disease. Now, scientists led by Wim Annaert at KU Leuven, Belgium, claim that’s because these fragments disrupt calcium flux. In
RESEARCH NEWS 2024-04-26 Research News Numerous studies have cast TREM2-expressing microglia as good guys in the Alzheimer’s brain, but new research suggests some play a darker role. In the April 18 Nature Neuroscience, researchers led by Michal Schwartz and Valery Krizhanovsky a
RESEARCH NEWS 2024-04-26 Research News To allow for the local translation of proteins that suit the ever-changing needs of the axon, neurons must ship transcripts from the soma to their outermost reaches. For thousands of these mRNAs, hitchhiking is their predominant mode of tran
RESEARCH NEWS 2024-04-24 Research News A new study adds to the evidence that a class of diabetes drugs could help Parkinson’s patients, even if only a little. In the April 4 New England Journal of Medicine, researchers led by Olivier Rascol at Toulouse University Hospital, France
RESEARCH NEWS 2024-04-20 Research News Among plasma biomarkers for Alzheimer’s disease, p-Tau217 stands tall as having the highest diagnostic accuracy. Now, in the March 23 Nature Communications, researchers led by Przemyslaw Kac, Thomas Karikari, and Kaj Blennow at the Universit
RESEARCH NEWS 2024-04-19 Research News The accumulation of neurofibrillary tangles is the common thread among all tauopathies, yet each amasses fibrils with a distinct fold at their core. What forces goad tau into twisting into these specific folds in the first place, and once fi
CONFERENCE COVERAGE 2024-04-19 Conference Coverage Microglia seem to play a hand in every aspect of Alzheimer’s pathogenesis, from the seeding and clearing of plaques to the traveling of tau to the dying of neurons. Scientists are pursuing therapeutics that both promote their neuroprot
