6234 RESULTS
RESEARCH NEWS 2024-09-27 Research News Long before carriers of autosomal-dominant AD mutations notice the first hints of memory loss, changes in their brains are well underway at the protein level. In a study published September 26 in Cell, scientists led by Carlos Cruchaga at Wa
RESEARCH NEWS 2024-09-27 Research News To boost the statistical power to find Alzheimer’s genes, geneticists often use endophenotypes—measurable characteristics of the disease—in place of clinical diagnoses. Case in point: A genome-wide association study on more than 3,000 tau PE
RESEARCH NEWS 2024-09-27 Research News When Aβ aggregates stoke synaptic fires, tau tangles put them out. This phenomenon, demonstrated in animal models, now gains support in a human study, published September 18 in Nature Neuroscience. Led by Sylvain Baillet at McGill University
RESEARCH NEWS 2024-09-26 Research News The amyloid cascade—plaques to tangles to cognitive decline—has become well established. Less well understood is what role inflammation and glial changes play. Now, by analyzing single-nuclei RNA-Seq data from more than 400 postmortem brains
RESEARCH NEWS 2024-09-25 Research News About two-thirds of people with Alzheimer’s disease are women, yet due to the challenges in studying X chromosomes, a genetic foundation for this has been difficult to uncover. Now, two large X-chromosome-wide association studies (XWAS) and
RESEARCH NEWS 2024-09-20 Research News Not all α-synuclein inclusions are created equal. That’s the upshot from a new stem cell approach to study “inclusionopathies,” such as Parkinson’s and Alzheimer’s diseases. As reported in the September issue of Neuron, scientists led by Vik
RESEARCH NEWS 2024-09-20 Research News Immunotherapy can remove extracellular amyloid plaques from Alzheimer’s brain, but has so far failed to clear intracellular tau tangles. Now, two papers propose a solution: tagging them for destruction by the cell’s own machinery. The papers
CONFERENCE COVERAGE 2024-09-19 Conference Coverage Alzheimer’s is a multifaceted disease, particularly in its sporadic, late-onset form. Myriad factors—genetics, environment, cardiovascular health, metabolism, and inflammation—contribute to a decades-long process. Generating animal mod
RESEARCH NEWS 2024-09-13 Research News Most people with ulcers and other gastrointestinal symptoms never develop neurological problems. But some 80 percent of people with Parkinson's disease have GI problems, such as acid reflux, irritable bowel syndrome, and constipation, w
RESEARCH NEWS 2024-09-12 Research News In Alzheimer’s disease, tau tangles accumulate in the temporal lobe and cortex, but spare other regions such as the cerebellum and brainstem. In a July 31 preprint on bioRxiv, scientists led by Huda Zoghbi at Baylor College of Medicine, Hous
COMMUNITY NEWS 2024-09-12 Community News On Tuesday September 10, Francisco Lopera died of cancer at his home in Medellin, Colombia. He was 73, and only just beginning to see his life’s work come to fruition. In fact, Lopera still had much to do. With his group, he was gearing up
RESEARCH NEWS 2024-09-06 Research News Could one tiny little amino acid derivative make Alzheimer’s disease a whole lot worse? In the August 25 Science, researchers led by Katrin Andreasson, Stanford University School of Medicine, report that, in response to oligomers of Aβ or ta
RESEARCH NEWS 2024-09-06 Research News More than any other biofluid, the cerebrospinal fluid is in intimate contact with the brain. What can the thousands of proteins churning within this brain bath tell us about how Alzheimer’s develops, and how to counteract this disease? A stu
RESEARCH NEWS 2024-09-06 Research News Decades before memory loss becomes a concern, the biological processes that lead to Alzheimer’s disease are underway in the brain. Could proteins in the blood sound the alarm for this pending crisis? Answering this question is a goal of prot
CONFERENCE COVERAGE 2024-09-04 Conference Coverage Ever since variants in the gene for TMEM106b were tied to frontotemporal dementia, Alzheimer’s, and other neurodegenerative diseases, this endolysosomal protein has been a head-scratcher for scientists. Its ability to surprise is exemp
