345049 RESULTS
COMMENT Summary of the work Li et al. developed a novel 3D co-culture model using iPSC-derived neurons, astrocytes, and microglia, and applied it for functional genomic screens to elucidate neuron-glia interactions. The authors first characterize some basic param
COMMENT Choi and colleagues employed a logical and systematic approach to screen for brain-derived extracellular vesicle (BDEV) markers, and to subsequently validate APLP1-positive EVs as “brain representatives” in plasma, using an impressive variety of methods.
COMMENT This paper presents a compelling study that characterizes APLP1 as a brain-specific biomarker for extracellular vesicles (EVs) detectable in plasma. The study utilizes a publicly available proteomic database to assess APLP1 expression, with validation thr
PAPER Ter-Ovanesyan D, Whiteman S, Gilboa T, Kowal EJ, Trieu W, Iyer S, Budnik B, Babila CM, Heimberg G, Burgess MW, Keshishian H, Carr SA, Regev A, Church GM, Walt DR
COMMENT This elegant study represents an exciting advance in using sophisticated human 3D cell culture models to investigate disease mechanisms, particularly those related to neuronal death and survival. Kampmann’s team demonstrated that unbiased CRISPRi screenin
RESEARCH NEWS 2025-01-24 Research News To better model how neurons fire and interact with glia, some scientists place the cells into a brain or grow them in an organoid. Others have produced little spheres of human neural tissue by combining neurons, astrocytes, and microglia, al
COMMENT This group has previously published similar studies conducting CRISPR interference-based screens individually on hPSC-derived induced neurons, microglia, and astrocytes. They unbiasedly identified functionally relevant gene targets of single guide RNAs, t
Houston Methodist
COMMENT iAssembloids are a scalable platform bridging the gap between 2D cultures and organoids. In this study, Martin Kampmann’s team combined a 3D co-culture system with a CRISPR-based genetic perturbation screen, revealing GSK3B’s role in modulating the oxidat
UCSFUnited States
University of NewcastleAustralia
PAPER Jacob C, Tollenaere M, Kachar H, Potier MC, De Deyn PP, Van Dam D
COMMENT The findings on Xenon-mediated induction of IFN-γ-producing T cells in the periphery and their role in modulating the pre-MGnD beneficial state in AD mouse models are intriguing. These results align with our previous work on the protective microglial stat
Danish Dementia Research CentreDenmark
PAPER Qarawani A, Naaman E, Ben-Zvi Elimelech R, Harel M, Sigal-Dror S, Ben-Zur T, Ziv T, Offen D, Zayit-Soudry S
No filters selected
