Alzheimer’s Risk Variants Found in Diverse Populations
A large meta-analysis turns up 16 new loci.
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After Immunotherapy, Amyloid Clearance Comes Down to Microglial Moods
Expression of TREM2, ApoE, and complement proteins correlated with extensive plaque clearance in response to Aβ immunotherapy.
Pretty in PINK1, Cryo-EM Reveals How Kinase Anchors to Mitochondria
Behold the first high-resolution structure of the human Parkinson’s-related kinase bound to mitochondrial membranes.
Confirmed: Women Accumulate Tangles Faster Than Do Men
Meta-analysis of six longitudinal studies finds that, among people who are amyloid-positive, tau PET signal rose faster in women.
In Amyloidosis, EphA4 Goads Astrocytes to Massacre Synapses
Inhibiting this receptor calmed reactive astrocytes and curbed their consumption of synapses in the hippocampus in a mouse amyloidosis model.
Sex Differences in Blood of Alzheimer’s and Parkinson’s Patients
The largest single-cell RNA-Seq study of blood cells finds more sex-specific expression changes in PD than AD. The database is accessible online.
Fragments of Tau’s Microtubule Binding Region Mess with Synapses
In rats, antibodies to the MTBR domain and adjacent C-terminal regions spared synaptic function.
Can Autoimmunity Spark Alzheimer’s Disease?
Electronic health records show that various autoimmune disorders put people at higher risk for AD.
With Age, Macrophages Chew up the Blood-CSF Barrier
Triggered by senescent cells, macrophages spew a protease that dissolves junctions between the cells that separate CSF from blood.
By Cleaving GABA(A) Receptors, BACE1 Lifts Lid on Hyperactivity
In a mouse model of amyloidosis, the BACE1 enzyme snipped subunits of the GABA(A) receptor, squelching its inhibitory function.
Do Specialized Glycoproteins Prop Up Blood-Brain Barrier?
Thinning out glycoproteins in the brain blood vessels of young mice allowed blood to leak into the brain. Promoting glycosylation in old mice strengthened the barrier.
Parkinson’s Risk Gene Speeds Spread of α-Synuclein Pathology
In neurons, FAM171A2 opens the door to toxic fibrils. An approved cancer drug slams it shut.
Hot News: DIAN Participant Defies Presenilin 2 Mutation
The man has lots of plaques but few tangles 18 years after his expected age of onset; potential protective factors include extensive heat shock protein expression.
Could Taking Down a DNA Repair Protein Stave Off Huntington’s?
In neurons from a person with HD, knocking down MSH3 kept CAG nucleotide expansions from growing even longer.
Plasma p-Tau217 Flags Alzheimer’s Pathology in Other Disorders
The marker detected plaques and tangles with 90 percent accuracy in almost 200 autopsy-confirmed frontotemporal dementia cases.
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