Paul Coleman on Visual loss and getting lost in Alzheimer's disease.

COMMENT A nice parcellation of a visual subtype of AD. 0 Paul_Coleman

Hiroshi Mori on Neurofibrillary degeneration in progressive supranuclear palsy and corticobasal degeneration: tau pathologies with exclusively "exon 10" isoforms.

COMMENT Such pioneering work using exon-specific antibody is highly important for understanding of tauopathy." 0 mori

Hiroshi Mori on Sequential phosphorylation of Tau by glycogen synthase kinase-3beta and protein kinase A at Thr212 and Ser214 generates the Alzheimer-specific epitope of antibody AT100 and requires a paired-helical-filament-like conformation.

COMMENT We need the detailed phosphorylation mechanism of tau to understand cell death. This is but one tau study, but is a step towards knowing the molecular mechanism of dementia. 0 mori

Peter Davies on The gene defects responsible for familial Alzheimer's disease.

COMMENT A good, authoritative, up-to-date- review. 0 peter.davies

Benjamin Wolozin on MPO and APOEepsilon4 polymorphisms interact to increase risk for AD in Finnish males.

COMMENT Further risk factor- important. 0 bwolozin

Richard Mayeux on Neuroprotective effects of estrogen against beta-amyloid toxicity are mediated by estrogen receptors in cultured neuronal cells.

COMMENT Continuation of evidence that estrogen may offer some degree of protection in Alzheimer's disease. 0 rpm2

Benjamin Wolozin on Cholesterol-dependent gamma-secretase activity in buoyant cholesterol-rich membrane microdomains.

COMMENT Abproduction is known to be dependent on cholesterol, but this article takes an important step forward by examining how cholesterol affects a particular secretase. 0 bwolozin

Paul Coleman on Pathologic correlates of apraxia in Alzheimer disease.

COMMENT An interesting study that correlates NFT and SP density in neocortex with ideomotor and constructive praxis in AD. It is not clear from the abstract how many neocortical areas were studied in the 23 patients examined- an issue to be considered in the anal

Nikolaos K. Robakis on Presenilin-1 mutations downregulate the signalling pathway of the unfolded-protein response.

COMMENT This is an important paper as it reports a new PS1 function and suggests a mechanism for cellular damage of the PS1 FAD mutations. 0 nikos.robakis

Paul Coleman on Is increased redox-active iron in Alzheimer disease a failure of the copper-binding protein ceruloplasmin?

COMMENT A bit of the puzzle that includes other proteins that interact and sequester iron in brain tissue. 0 Paul_Coleman

Hiroshi Mori on Dementia with Lewy bodies.

COMMENT Studies on DLB grow rapidly based on clinical and pathological reasons. However, there is some confusion in naming and categorization. This is a new study attempting to clarify this confusion; more evidence must be accumulated. 0 mori

Hiroshi Mori on Diffuse plaques in the striatum in Alzheimer disease (AD): relationship to the striatal mosaic and selected neuropeptide markers.

COMMENT This study may suggest the heterogeneity in amyloid plaques. Its heterogeneity is interesting if they come from the different molecular mechanisms but not from chance origins of neurons per se. 0 mori

Hiroshi Mori on Reduction in amyloid A amyloid formation in apolipoprotein-E-deficient mice.

COMMENT This is a further in vivo evidence that ApoE is involved in amyloidogenesis. The authors used adenovirus to carry ApoE for ApoE-deficient mice to complete its function in amyloidogenesis. 0 mori

Peter Davies on A rescue factor abolishing neuronal cell death by a wide spectrum of familial Alzheimer's disease genes and Abeta.

COMMENT There are some unusual things in this paper. They have a mRNA that is almost 1600 bases long, with an open reading frame of 75 bases, coding for a protein (peptide really) of 24 amino acids. Very unusual. When I run the sequence in Blast, it seems to be f

Carl Cotman on Amyloid deposition is associated with c-Jun expression in Alzheimer's disease and amyloid angiopathy.

COMMENT In general consistent with previous studies by our group and others. 0 cwcotman