Nikolaos K. Robakis on Two amyloid precursor protein transgenic mouse models with Alzheimer disease-like pathology.

COMMENT If the claim of this paper on the induction of tau pathology by APP mutations is replicated, these mice will be the best available AD model. 0 nikos.robakis

Elliott Mufson on Cognitive enhancement therapy for Alzheimer's disease. The way forward.

COMMENT Useful. 0 emufson

Hiroshi Mori on Effects of specific protease inhibitors on amyloid beta-protein 42 secretion.

COMMENT It is still open a question whether Ab42 is the source of Ab40. Any examination is welcome to study this relationship. 0 mori

Paul Coleman on Hippocampal volume in patients with alcohol dependence.

COMMENT 'Alcohol consumption should he accounted for in studies of hippocampal damage.' Another variable to consider. 0 Paul_Coleman

Alison Goate on D10S1423 identifies a susceptibility locus for Alzheimer's disease in a prospective, longitudinal, double-blind study of asymptomatic individuals.

COMMENT This paper reports that the 234 bp allele of D10S1423 in conjunction with APOE4 is a strong predictor of AD. However, this is based upon only 18 incident cases of AD, thus more data is required to see if this holds up in larger samples. The marker is on t

Hiroshi Mori on Okadaic acid-induced apoptosis in neuronal cells: evidence for an abortive mitotic attempt.

COMMENT Okadaic acid is a useful tool to enhance phosphorylation in cells and interesting with regard to neuronal apototic cell death. Its molecular mechanism in apotosis is still unclear but provides us an experimental condition [for elucidating apoptotic mechan

Hiroshi Mori on Mutation screening in exons 3 and 4 of alpha-synuclein in sporadic Parkinson's and sporadic and familial dementia with Lewy bodies cases.

COMMENT Sporadic cases of PD differ from FPD. It remains to be discovered whether there are common pathological changes beside the present mutations. 0 mori

Paul Coleman on Nonsteroidal anti-inflammatory drug use and Alzheimer-type pathology in aging.

COMMENT The abstract of this paper concludes that the mechanism of NSAID effect on AD 'is more likely to be through the suppression of microglial activity than by inhibiting the formation of SP or neurofibrillary tangles.' This population-based neuropat

Hiroshi Mori on Cerebral amyloid angiopathy: amyloid beta accumulates in putative interstitial fluid drainage pathways in Alzheimer's disease.

COMMENT There are a small number of papers reporting amyloid deposition as compared with plaque deposition. On the basis of the deposition burden, amyloid angiopathy should be studied more extensively as this paper. 0 mori

Gerry Fischbach on Immunoreactivity of growth inhibitory factor in normal rat brain and after stab wounds--an immunocytochemical study using confocal laser scan microscope.

COMMENT How is GIF defined here? 0 gf224

Richard Mayeux on Effect of anti-inflammatory medications on neuropathological findings in Alzheimer disease.

COMMENT Important study showing little protective effect of anti-inflammatory drugs. 0 rpm2

Nikolaos K. Robakis on Modification of tau to an Alzheimer's type protein interferes with its interaction with microtubules.

COMMENT This paper suggests that in AD tau is modified by AGE and this modifications result in functional abnormalities of the microtubules system of the cell. An interesting observation. If replicated it going to be important for AD. 0 nikos.robakis

Elliott Mufson on Mechanism of Alzheimer neurofibrillary degeneration and the formation of tangles.

COMMENT Interesting. 0 emufson

Nikolaos K. Robakis on Transgenic Drosophila expressing human amyloid precursor protein show gamma-secretase activity and a blistered-wing phenotype.

COMMENT This is an interesting paper as it suggests a function for APP in cell adhesion/signaling. The APP FAD mutations may disturb this function in AD independently of beta A4 generation. 0 nikos.robakis

Hiroshi Mori on Initial results of a genome survey for novel Alzheimer's disease risk genes: association with a locus on the X chromosome.

COMMENT There is a discussion that suggests a weak domonancy of AD in women as comapred with in men. This may be the first document to suggest such factor that promotes AD on X-chromosome. 0 mori