Hiroshi Mori on Mutant human presenilin 1 protects presenilin 1 null mouse against embryonic lethality and elevates Abeta1-42/43 expression.

COMMENT This is extremely an important paper. Axial skeleton malformation and CNS defects in PS1-null mice is rescued by both wild and mutated PS1. It indicates that PS1 plays at least two roles involved in axial skeletal formation and amyloid formation. 0 mori

Hiroshi Mori on Fibrilization in mouse senile amyloidosis is fibril conformation-dependent.

COMMENT This is interesting for in vivo model to discuss the conformational significance of seed fibrils. 0 mori

Hiroshi Mori on No association detected between very-low-density lipoprotein receptor (VLDL-R) and late-onset Alzheimer's disease in Hong Kong Chinese.

COMMENT This is negative data but is important to deny the previous report to show the potent association between VLDL-R and AD. 0 mori

John Hardy on Determinants of 4-repeat tau expression. Coordination between enhancing and inhibitory splicing sequences for exon 10 inclusion.

COMMENT The importance of the control of tau splicing is clearly critical to the understanding of tau biology in tangle diseases. This is a complex and tightly controlled process as this reference illustrates. 0 J.Hardy

Hiroshi Mori on Frontotemporal dementia and Parkinsonism linked to chromosome 17: a new group of tauopathies.

COMMENT Frontotemporal dementia is interesting because of the similarity to AD but is a different disorder. As it is heterologous, its causal genes may be several. Further genetic analysis is welcome. 0 mori

Paul Coleman on Accumulation of cyclin-dependent kinase 5 (cdk5) in neurons with early stages of Alzheimer's disease neurofibrillary degeneration.

COMMENT This work is important for cross-cultural epidemeological studies of AD. 0 Paul_Coleman

Elliott Mufson on Psychiatric correlates of MR deep white matter lesions in probable Alzheimer's disease.

COMMENT Interesting 0 emufson

Hiroshi Mori on Beta-amyloid induces local neurite degeneration in cultured hippocampal neurons: evidence for neuritic apoptosis.

COMMENT The practical evidence is provided by this article to show the local neurite degeneration although it is a problem whether we can call this neurite apoptosis. 0 mori

Elliott Mufson on The inhibitory effects of beta-amyloid on glutamate and glucose uptakes by cultured astrocytes.

COMMENT Interesting. 0 emufson

Hiroshi Mori on Isoform-specific effects of human apolipoprotein E on brain function revealed in ApoE knockout mice: increased susceptibility of females.

COMMENT Experiments involving Tg mice with human gene without the mouse gene will increasingly yeild more clear data like this paper. 0 mori

Hiroshi Mori on Intracellular inositol (1,4,5)-trisphosphate receptor levels are preserved in Alzheimer's disease platelets.

COMMENT Calcium metabolism and its signal in AD brain is one of the most interesting topics, especially when we consider the possible function of the signal transduction disturbance in the pathogenesis. 0 mori

Carl Cotman on Cognitive and neurobiologic markers of early Alzheimer disease.

COMMENT Important issue, thoughtfully presented 0 cwcotman

Hiroshi Mori on High-throughput quantitative histological analysis of Alzheimer's disease pathology using a confocal digital microscanner.

COMMENT This is important for all morphologists to analyze quantitatively AD pathology. 0 mori

Benjamin Wolozin on Presenilin-1 mutations in Alzheimer's disease.

COMMENT Mutations in PS1 have been shown to increase production of Ab42. This current publication suggests that mutations in PS1 might also affect cleavage at the N-terminus of Ab, leading to production of truncated Ab. 0 bwolozin

Benjamin Wolozin on Upregulation of BiP and CHOP by the unfolded-protein response is independent of presenilin expression.

COMMENT Raises into question previous information about PS1 and PS2. 0 bwolozin