Hiroshi Mori on Transgenic expression of the shortest human tau affects its compartmentalization and its phosphorylation as in the pretangle stage of Alzheimer's disease.

COMMENT It is highly important to make Tg mouse bearing tau. This is a new animal different from Dr. Goedert's mouse. 0 mori

Paul Coleman on Physostigmine results in an increased decrement in brain glucose consumption in Alzheimer's disease.

COMMENT This paper suggests that the weak clinical response of AD patients to cholinergic agents may be due to cholinergic depression of glucose consumption. Alternative explanations may also be possible. 0 Paul_Coleman

Carl Cotman on Microglial cell activation in aging and Alzheimer disease: partial linkage with neurofibrillary tangle burden in the hippocampus.

COMMENT Interesting [that neuropathologic changes at the origin o fthe perforant pathway were correlated significantly with orthograde microglial cell activation in the termination field.] 0 cwcotman

Paul Coleman on Apparent mtDNA heteroplasmy in Alzheimer's disease patients and in normals due to PCR amplification of nucleus-embedded mtDNA pseudogenes.

COMMENT This is an important caution to studies of mt DNA mutations in AD (as well as to other studies using PCR). 0 Paul_Coleman

John Olney on Involvement of neuronal anion exchange proteins in cell death in Alzheimer's disease.

COMMENT This is a review article that discusses the potential role of anion exchange proteins in AD. The main value of the article is that it reviews a mechanism that is potentially relevant to AD but has not received much attention. Although the abstract does no

Hiroshi Mori on Characterization of 8-epiprostaglandin F2alpha as a marker of amyloid beta-peptide-induced oxidative damage.

COMMENT It is interesting in consideration of molecular mechanism of superoxide on AD pathogenesis and related therapy. 0 mori

Edward Koo on The selective muscarinic M1 agonist AF102B decreases levels of total Abeta in cerebrospinal fluid of patients with Alzheimer's disease.

COMMENT First good evidence that the in vitro effects of muscarinic stimulation can be seen physiologically. 0 edkoo

Elliott Mufson on Vascular variant of Alzheimer's disease characterized by severe plaque-like beta protein angiopathy.

COMMENT Interesting. 0 emufson

Nikolaos K. Robakis on Striation is the characteristic neuritic abnormality in Alzheimer disease.

COMMENT This is an interesting paper because it suggests a specific pathological pattern for dystrophic neurites. This information should help to understand the mechanism of the cytoskelatal abnormalities in AD. 0 nikos.robakis

Paul Coleman on Overexpression of alpha-internexin causes abnormal neurofilamentous accumulations and motor coordination deficits in transgenic mice.

COMMENT Of interest with respect to cytoskeletal disruption, behavioral deficits and neuronal loss. 0 Paul_Coleman

Nikolaos K. Robakis on Genetic association of alpha2-macroglobulin with Alzheimer's disease in a Finnish elderly population.

COMMENT This is an interesting report as it confirms earlier findings that alpha-2-macroglobulin is linked to AD. The failure of other groups to find such linkage may then be explained either by population bias or by the age of the subjects. 0 nikos.robakis

Hiroshi Mori on Intracerebral hemorrhage in two patients with Down's syndrome and cerebral amyloid angiopathy.

COMMENT CAA is an important cause of hemorrhages in brains of the elderly, patients with Alzheimer's disease, Down's syndrome (DS), and amyloidosis of the Dutch type. [There is] little information reported on the complex [forms] of the disease. 0 mori

Hiroshi Mori on Mapping the APP/presenilin (PS) binding domains: the hydrophilic N-terminus of PS2 is sufficient for interaction with APP and can displace APP/PS1 interaction.

COMMENT This is the first paper to show the PS-2 domain to bind APP. 0 mori

Paul Coleman on Visual loss and getting lost in Alzheimer's disease.

COMMENT A nice parcellation of a visual subtype of AD. 0 Paul_Coleman

Hiroshi Mori on Neurofibrillary degeneration in progressive supranuclear palsy and corticobasal degeneration: tau pathologies with exclusively "exon 10" isoforms.

COMMENT Such pioneering work using exon-specific antibody is highly important for understanding of tauopathy." 0 mori