Pradier L, Carpentier N, Delalonde L, Clavel N, Bock MD, Buée L, Mercken L, Tocqué B, Czech C. Mapping the APP/presenilin (PS) binding domains: the hydrophilic N-terminus of PS2 is sufficient for interaction with APP and can displace APP/PS1 interaction. Neurobiol Dis. 1999 Feb;6(1):43-55. PubMed.
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Osaka City University Medical School
This is the first paper to show the PS-2 domain to bind APP.
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