Gerard Schellenberg on Genetic evidence for the involvement of tau in progressive supranuclear palsy.

COMMENT Indicates that PSP/NFT's may be related to genetic alterations in or around tau, a region also implicated in frontotemporal lobe dementia in autosomal dominant families. 0 zachdad

Huntington Potter on DNA replication precedes neuronal cell death in Alzheimer's disease.

COMMENT This paper emphasizes the apparent DNA replication of all chromosomes in neurons in AD patients, rather than also mentioning the aneuploidy for specific chromosomes including chromosome 21 that he reported last summer and which is equally consistent with

Gunnar Gouras on Stimulation of beta-amyloid precursor protein trafficking by insulin reduces intraneuronal beta-amyloid and requires mitogen-activated protein kinase signaling.

COMMENT We appreciate the analysis/comments of our paper by Dean Hartley, but want to stress that this

Dean Hartley on Stimulation of beta-amyloid precursor protein trafficking by insulin reduces intraneuronal beta-amyloid and requires mitogen-activated protein kinase signaling.

COMMENT More glucose, I mean, more food for thought. The role of insulin in the brain is still emerging and this interesting paper by Gasparini and colleagues presents a novel mechanism by which insulin affects the trafficking of A-beta. They find that insulin, t

Mike Miguel Pappolla on Inhibition of Alzheimer beta-fibrillogenesis by melatonin.

COMMENT Regarding the above comment by Dr Mori, the inhibition of beta-sheet structures and amyloid

Hiroshi Mori on NACP, a presynaptic protein, immunoreactivity in Lewy bodies in Parkinson's disease.

COMMENT NACP is proposed to be the cause of familial PD and its occurrence in Lewy body enhances this idea. We need more information on this matter using other different Lewy body-disease. Such studies are suppposed to give a new insight. 0 mori

Peter Nelson on Clinicopathologic studies in cognitively healthy aging and Alzheimer's disease: relation of histologic markers to dementia severity, age, sex, and apolipoprotein E genotype.

COMMENT A high-quality study from a well-respected group of clinicians and pathologists. 0 ptnelson

Peter Nelson on Ectopic cell cycle proteins predict the sites of neuronal cell death in Alzheimer's disease brain.

COMMENT I think that the evidence of disruption/change of cell cycle protein expression in Alzheimers disease is very intriguing. 0 ptnelson

Peter Nelson on Light and electron microscopic immunolocalization of presenilin 1 in abnormal muscle fibers of patients with sporadic inclusion-body myositis and autosomal-recessive inclusion-body myopathy.

COMMENT An increasingly compelling model of AD pathology is IBM. 0 ptnelson

Peter Nelson on Complete genomic screen in late-onset familial Alzheimer's disease.

COMMENT Insight into some possible new loci of AD genes. 0 ptnelson

Eliezer Masliah on Dopamine Renders α-Synuclein Toxic to Neurons

COMMENT We need to remember that many studies, such as this one by Yankner, involve in vitro systems that are not sustained by a complex network, as is the case in vivo in transgenic mice. This is also relevant to Alzheimer disease models. Specifically, activatio

Michael Schlossmacher on Dopamine Renders α-Synuclein Toxic to Neurons

COMMENT I found this paper quite intriguing and very much relevant to PD. I believe it provides a very plausible model that tries to address the long-standing question of the fairly selective neurodegenerative process seen in PD (i.e. dopaminergic neuronal vulner

Tennore Ramesh on Dynamitin in Motor Neurons: Dynamite for ALS Research?

COMMENT The paper by LaMonte et al. adds a new twist to the complex history of axonal transport in ALS. The demonstration that disruption of axonal transport can cause ALS-like disease is very interesting. The authors demonstrate that overexpression of dynamitin,

Tennore Ramesh on The Cell Cycle and Alzheimer’s Disease—Let's Unite for Division!

COMMENT Reply by Tennore Ramesh I agree with Dr. Wolozin. Many cell cycle proteins are regulated by the proteasome and that may be a simple starting point. CDk5 is shown to be altered in ALS. P35, the neuron-specific activator of CDK5, is regulated by the ubiquit

Erika Holzbaur on Dynamitin in Motor Neurons: Dynamite for ALS Research?

COMMENT Response by Erika Holzbaur The multifunctional nature of the dynein/dynactin pathway in vertebrates, including key roles in mitotic spindle assembly, axonal transport, and organelle positioning, makes it challenging to dissect the specific functional mech