Hiroshi Mori on Cerebrovascular muscle atrophy is a feature of Alzheimer's disease.

COMMENT Smooth muscle atrophy was independent of adjacent amyloid-beta deposition, suggesting that vascular change does not segregate with plaque formation. 0 mori

Hiroshi Mori on Interaction of apolipoprotein E epsilon 4 with other genetic and non-genetic risk factors in late onset Alzheimer disease: problems facing the investigator.

COMMENT Apolipoprotein E4 allele is established to be the major susceptibility gene for late onset Alzheimer Disease (AD) but still needs more study to clarify its function. This is valuable on the viewpoint of genetic association study. 0 mori

Benjamin Wolozin on Dementia and neurodevelopmental predisposition: cognitive dysfunction in presymptomatic subjects precedes dementia by decades in frontotemporal dementia.

COMMENT With the advent of molecular markers identifying mutations in tau associated with disease, it is now possible to identify individuals at risk for disease before onset of overt clinical symptoms. This presents an exciting opportunity to investigate how the

Edward Koo on Role of the omentum in the treatment of Alzheimer's disease.

COMMENT Controversial approach to AD treatment. Must await new trial data. Current review if from originator of technique. 0 edkoo

Paul Coleman on Absence of aluminium in neurofibrillary tangles in Alzheimer's disease.

COMMENT A confirmation of previous data that come to the same conclusion. 0 Paul_Coleman

Hiroshi Mori on Synaptic transmission and hippocampal long-term potentiation in transgenic mice expressing FAD-linked presenilin 1.

COMMENT Electrophysiological evidence is strong index to show the dysfunction of Tg mouse with PS-1 mutation. 0 mori

Elliott Mufson on Potent inhibition of interleukin-6 expression in a human astrocytoma cell line by tenidap.

COMMENT Interesting. 0 emufson

Gerry Fischbach on Effect of hippocampal sympathetic ingrowth and cholinergic denervation on hippocampal phospholipase C activity and G-protein function.

COMMENT An interesting, well-controlled study pointing to a key role for G-protein activation following change in ascending cholinergic innervation. May be relvant in AD 0 gf224

Paul Coleman on Age-related alteration of PKC, a key enzyme in memory processes: physiological and pathological examples.

COMMENT PKC has been shown to phosphorylate GAP-43/F1/B-50 on Ser residues. Routtenberg and others have shown that this phosphorylation of GAP-43/F1 is important for learning and memory, and Martzen et al. have shown that the distribution of phosphorylated GAP-43

Paul Coleman on Cleavage of Alzheimer's amyloid precursor protein (APP) by secretases occurs after O-glycosylation of APP in the protein secretory pathway. Identification of intracellular compartments in which APP cleavage occurs without using toxic agents that interfere

COMMENT This is very interesting for a variety of reasons: 1. It may shed additional light on the processing of APP, 2. Hart and others have suggested that glycosylation may be reciprocal to phosphorylation- they share many similar potential sites and 3. Although

Benjamin Wolozin on Sign of lipid peroxidation as measured in the urine of patients with probable Alzheimer's disease.

COMMENT This could represent a noninvasive biochemical test for diagnosis of AD. 0 bwolozin

Hiroshi Mori on Region- and cell-type-specific pattern of tau phosphorylation in dog brain.

COMMENT The mutation is important to know the function of the molecule. Any articles like this paper are welcome to study presenilin. The Polish mutation is particularly interesting for its extremely high effect on amyloid production. 0 mori

Hiroshi Mori on Apoptosis decision cascades and neuronal degeneration in Alzheimer's disease.

COMMENT This group is undoubtedly one of the top research groups that provides the most concrete and firm evidence showing amyloid neurotoxicities. Their hypothesis is always challengeable and fascinating. 0 mori

Carl Cotman on The autonomic-related cortex: pathology in Alzheimer's disease.

COMMENT New lead in an understudied aspect 0 cwcotman

Paul Coleman on Granule cells in aging rats are sexually dimorphic in their response to estradiol.

COMMENT A well done study that used intracellular dye injection to define dendritic spines and processes. 0 Paul_Coleman