Hiroshi Mori on Alzheimer's presenilin-1 mutation potentiates inositol 1,4,5-trisphosphate-mediated calcium signaling in Xenopus oocytes.

COMMENT Another paper showing that calcium ion is another central molecule for amyloid hypothesis. 0 mori

Paul Coleman on Selective decline in memory function among healthy elderly.

COMMENT A study that shows the specificity of age-related memory decline. The authors speculate that the memory decline described may be anatomically localized to the hippocampal formation, which is consistent with the finding of normal, age-related neuronal loss

Edward Koo on Cortical inflammation in Alzheimer disease but not dementia with Lewy bodies.

COMMENT THIS STUDY SUGGESTS THAT MAYBE THE INFLAMMATORY CHANGES IN AD MAYBE SPECIFIC TO NEURITIC PLAQUES. 0 edkoo

Carl Cotman on Absence of the A1252G mutation in alpha 1-antichymotrypsin in a North American population suffering from dementia.

COMMENT Interesting 0 cwcotman

Hiroshi Mori on Treatment outcome of tacrine therapy depends on apolipoprotein genotype and gender of the subjects with Alzheimer's disease.

COMMENT The different effect of tacrine may be a clue to understanding the pathological role by ApoE. 0 mori

Hiroshi Mori on Amyloid-beta induces chemokine secretion and monocyte migration across a human blood--brain barrier model.

COMMENT The story is interesting. I wonder the reaction by Abeta1-40 beside Abeta1-42 because the former is secreted in a much higher amount. 0 mori

Carl Cotman on Hippocampus in delay eyeblink classical conditioning: essential for nefiracetam amelioration of learning in older rabbits.

COMMENT Interesting 0 cwcotman

Nikolaos K. Robakis on Soluble pool of Abeta amyloid as a determinant of severity of neurodegeneration in Alzheimer's disease.

COMMENT This report shifts the importance of Abeta in AD from the amyloid depositions to a soluble Abeta peptide. This shift is nessasary as there is good evidence that amyloid plaques may not be responsible for AD. 0 nikos.robakis

Hiroshi Mori on Detection of apolipoprotein E/dimeric soluble amyloid beta complexes in Alzheimer's disease brain supernatants.

COMMENT The interaction of Abeta with apoE may be a hint for the treatment of AD because it is the possible regulation step to clear deposition of Abeta 0 mori

Nikolaos K. Robakis on Prostaglandins act as neurotoxin for differentiated neuroblastoma cells in culture and increase levels of ubiquitin and beta-amyloid.

COMMENT This is an interesting paper. It shows that besides the FAD mutation, cellular Abeta can increase in response to other toxic conditions including neuronal stress. That has implications on the putative role of amyloid in AD. 0 nikos.robakis

Edward Koo on Treatment with controlled-release lovastatin decreases serum concentrations of human beta-amyloid (A beta) peptide.

COMMENT This is a nice, though small, study. I suspect this is the beginning of a series of human studies showing that statins lower abeta, as has been shown in transgenic mice. Will this is effective AD treatment or prevention? 0 edkoo

Paul Coleman on Immunohistochemical and in situ analysis of amyloid precursor-like protein-1 and amyloid precursor-like protein-2 expression in Alzheimer disease and aged control brains.

COMMENT The abstract states "we show that APLP1 and APLP2 mRNA are expressed primarily in the granule cells of the dentate gyrus, in areas CA1-CA3, and subiculum". It is noteworthy that this localization includes affected and relatively unaffected regio

Paul Coleman on The Alzheimerization of aging: a brief update.

COMMENT If one considers NIH (not only NIA) support for research in the broader context of research on age-related morbidity and mortality, including heart disease, stroke, arthritis, cancer, etc., etc., one would almost certainly come to the conclusion that Alzh

Benjamin Wolozin on Staging of neurofibrillary degeneration caused by human tau overexpression in a unique cellular model of human tauopathy.

COMMENT interesting study examining the detailed staging of tauopathies. 0 bwolozin

Nikolaos K. Robakis on Genetic studies on chromosome 12 in late-onset Alzheimer disease.

COMMENT The Wu and Rogaeva papers on Chromosome 12 are interesting. They contradict each other on the very important question of the potential role of Chromosome 12 on AD. Apparently the two groups interpret the data differently. A lod score of 1.91, however, in