Paul Coleman on Increased glyceraldehyde 3-phosphate dehydrogenase levels in the brain of patients with Down's syndrome.

COMMENT This is particularly interesting since G3PD is used as a loading control in many studies. 0 Paul_Coleman

Elliott Mufson on High density lipoprotein decreases beta-amyloid toxicity in cortical cell culture.

COMMENT Interesting study 0 emufson

Hiroshi Mori on Novel large apolipoprotein E-containing lipoproteins of density 1.006-1.060 g/ml in human cerebrospinal fluid.

COMMENT This paper may be important for the new lipid complex which is invovled in ApoE function of forming AD pathogenesis. 0 mori

Carl Cotman on Genetic association studies between dementia of the Alzheimer's type and three receptors for apolipoprotein E in a Caucasian population.

COMMENT Interesting 0 cwcotman

Alison Goate on Apolipoprotein E polymorphism in elderly east Africans.

COMMENT More data suggesting that APOE4 does not have a major impact on risk for ad among people of African origin 0 goate

Elliott Mufson on Alzheimer's PS-1 mutation perturbs calcium homeostasis and sensitizes PC12 cells to death induced by amyloid beta-peptide.

COMMENT Interesting 0 emufson

Elliott Mufson on Molecular forms of somatostatin-like immunoreactivity in the cerebrospinal fluid of patients with senile dementia of the Alzheimer type.

COMMENT Interesting. 0 emufson

Benjamin Wolozin on Synucleins are a novel class of substrates for G protein-coupled receptor kinases.

COMMENT This paper provides a potentially important functional link for synucleins. 0 bwolozin

Paul Coleman on The beta-amyloid precursor protein of Alzheimer's disease enhances neuron viability and modulates neuronal polarity.

COMMENT Useful data if not over-interpreted. To what extent can in vitro data be extended to the in vivo human AD brain? 0 Paul_Coleman

Edward Koo on Loss of basal forebrain P75(NTR) immunoreactivity in subjects with mild cognitive impairment and Alzheimer's disease.

COMMENT Another pathological marker for mci? 0 edkoo

Elliott Mufson on Aging and Alzheimer's disease: lessons from the Nun Study.

COMMENT Noteworthy. 0 emufson

Hiroshi Mori on Argyrophilic tau-positive twisted and non-twisted tubules in astrocytic processes in brains of Alzheimer-type dementia: an electron microscopical study.

COMMENT Astrocytic tau sturucture is recently popular because of its aberrant occurrence in pathological situations. This morphologically unique sturucture is interesting and may be a clue to understanding neuronal PHF or other tau inclusions. 0 mori

Elliott Mufson on Controlling amyloid beta-peptide fibril formation with protease-stable ligands.

COMMENT Interesting. 0 emufson

Paul Coleman on Huntingtin protein colocalizes with lesions of neurodegenerative diseases: An investigation in Huntington's, Alzheimer's, and Pick's diseases.

COMMENT It is not clear how the conclusion of this paper that 'cells in the CNS appear senstivie to damage by the aggregated, toxic levels of huntingtin' relates to the widespread expression of huntingtin throughout the brain and body. 0 Paul_Coleman

Hiroshi Mori on Accumulation and aggregation of amyloid beta-protein in late endosomes of Niemann-pick type C cells.

COMMENT It is not easy to understand the pathological function of Abeta42 in NPC. 0 mori