Perez RG, Zheng H, van der Ploeg LH, Koo EH.
The beta-amyloid precursor protein of Alzheimer's disease enhances neuron viability and modulates neuronal polarity.
J Neurosci. 1997 Dec 15;17(24):9407-14.
PubMed.
APP must be studied both for its role in pathogenesis of AD and basic housekeeping molecule for neurons. The authors try to clarify the latter purpose using APP-knockout mice.
Comments
Banner Research Institute
Useful data if not over-interpreted. To what extent can in vitro data be extended to the in vivo human AD brain?
Osaka City University Medical School
APP must be studied both for its role in pathogenesis of AD and basic housekeeping molecule for neurons. The authors try to clarify the latter purpose using APP-knockout mice.
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