Pascale A, Govoni S, Battaini F.
Age-related alteration of PKC, a key enzyme in memory processes: physiological and pathological examples.
Mol Neurobiol. 1998 Feb;16(1):49-62.
PubMed.
PKC has been shown to phosphorylate GAP-43/F1/B-50 on Ser residues. Routtenberg and others have shown that this phosphorylation of GAP-43/F1 is important for learning and memory, and Martzen et al. have shown that the distribution of phosphorylated GAP-43 between membrane and cytosol fractions of brain extract is altered in AD.
Comments
Banner Research Institute
PKC has been shown to phosphorylate GAP-43/F1/B-50 on Ser residues. Routtenberg and others have shown that this phosphorylation of GAP-43/F1 is important for learning and memory, and Martzen et al. have shown that the distribution of phosphorylated GAP-43 between membrane and cytosol fractions of brain extract is altered in AD.
Osaka City University Medical School
Racial comparison of ApoE alleles will provide some information of molecular mechanism of the disease etiology.
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