The Antibodies database was archived in December 2022 and is no longer being updated. The Antibodies database is being supplanted by the AlzAntibodies database, which aims to provide detailed descriptions of selected antibodies.

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Antibodies

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	Name	Source	Clonality & Isotype	Host & Formulation	Method	Reactivity	Immunogen/ Epitope	Specificity	Availability
APP, APLP, AICD From labs (5)
	APP	anti-APP C7(Dr. Dennis Selkoe,Harvard Univ. Medical School, Boston, MA)Reference: Puglielli, 2001,by Yu, 2001	polyclonal	Rabbit	-	-	last 20 residues of APP		-
	APP	anti-APP C9(Dr. Dennis Selkoe,Harvard Univ. Medical School, Boston, MA)References:Muresan, 2009Sato, 2007	polyclonal	Rabbit	-	-	synthetic peptide corresp. to APP732-751, (APP751 numbering)		-
	APP	anti-APP α-1(Dr. Dennis Selkoe,Harvard Univ. Medical School, Boston, MA	polyclonal	Rabbit	-	Human	synthetic peptide of residues 649-664	APP	-
	APP	R1736(Dr. Dennis Selkoe,Harvard Univ. Medical School, Boston, MA)Reference: Maier, 2008,	polyclonal	Rabbit (antiserum)	-	Rodent (various), Human	immunogen = synthetic peptide of amino acids 595–611 of APP	APP epitope corresponds to positions -2 to +15 of human Abeta, and it presents 90%(15 out of 17 amino acids) of sequence homology with the hamster sequence which is identical to other rodents such as mouse	-
	APP, full length	anti-APP C8(Dr. Dennis Selkoe,Harvard Univ. Medical School, Boston, MA)References: Davis, 2010Senechal, 2008Wang, 2007	polyclonal	Rabbit	-	Mammal (various), Human	residues 676-695, comprising the 20 C-terminal amino acids of human βAPP cytoplasmic domain.Paper, Selkoe et al.	recognizes full length APP and all CTFs	-
APP, APLP, AICD From manufacturers (1)
	APP	Synaptic Systems Cat# 127 002	polyclonal	Rabbit (antiserum, lyophilized. )	-	Human, Mouse, Rat, Chicken, Frog	Synthetic peptide GYENPTYKFFEQMQN corresponding to the C-terminus of APP coupled to key-hole limpet hemocyanin via an added N-terminal cysteine residue.	Specific for APP.	Confirmed available March 2014
Amyloid-β From labs (2)
	APP N-terminus (1D1)	-	monoclonal IgG1	Rat (supernatant)	-	Human	This antibody was raised against the native human APP ectodomain (isoform 695, which lacks the KPI domain). The epitope is believed to lie between amino acids 40 and 64.	Specific to human APP. Does not cross-react with mouse, rat, dog, or guinea pig.	Contact Stefan Lichtenthaler
	APP N-terminus (7H6)	-	monoclonal IgG1	Rat (supernatant)	-	Human	This antibody was raised against the native human APP ectodomain (isoform 695, which lacks the KPI domain). The epitope is believed to lie between amino acids 40 and 64.	Specific to human APP. Does not cross-react with mouse, rat, dog, or guinea pig.	Contact Stefan Lichtenthaler
Amyloid-β From manufacturers (9)
	β-Amyloid, N-terminal truncated (1-57)	Synaptic Systems	monoclonal IgG2b	Mouse (affinity purified, buffered, azide, lyophilized)	-	Human, Mouse, Rat	Balb/c mice were immunized with a KLH-coupled pyroglutamate-Abeta-peptide with the peptide pE F R H D-C.After preparation of the lymph nodes, cells were fused with the myeloma cell line P3-963-Ag8	reactive to N-terminal truncated Abeta 3-X starting with pyroglutamate (pGlu, pE). Does not cross-react with N-terminal truncated Abeta 11-X starting with pGlu.	-
	β-Amyloid, N-terminal truncated (2-48)	Synaptic Systems	monoclonal IgG1	Mouse (affinity purified, buffered, azide, lyophilized)	-	Human, Mouse, Rat	Balb/c mice were immunized with a KLH-coupled pyroglutamate-Abeta-peptide with the peptide pEFRHD-C.After preparation of the lymph nodes, cells were fused with the myeloma cell line P3-963-Ag8	reactive to N-terminal truncated Abeta 3-X starting with pyroglutamate (pGlu, pE). Does not cross-react with N-terminal truncated Abeta 11-X starting with pGlu.	-
	Amyloid-β (N-terminal)-biotin (82E1-biotin)	IBL Cat# 10326	monoclonal IgG1	Mouse (affinity purified, lyophilized product from 1% BSA in PBS containing 0.05% NaN3; biotin-tagged)	-	Human	immunogen = synthetic peptide for human Amyloid β (1-16) (DAEFRHDS GYEVHHQK)	Amyloid β and β-CTF N-terminal specific; reacts with both soluble and fibrillar Aβ to a similar degree; no reaction with holo-APP	-
	MOAB-2	Biosensis Cat# M-1586-100	monoclonal IgG2b	Mouse (Lyophilized; Protein A purified; 0.02 M potassium phosphate, 0.15 M sodium chloride, 0.01% sodium azide; pH 7.2)	-	Human, Rat	Epitope maps to residues 1-4 of human Aβ42 and Aβ40 (DAEF)	Reacts with the N-terminal end of Aβ (amino acids 1-4). Appears to detect monomeric, oligomeric, and fibrillar forms of Aβ. Greater sensitivity for Aβ42 than Aβ40. Does not cross react with holo-APP or APP-CTFs.	Confirmed available March 2015.
	MOAB-2	Abcam Cat# ab126649	monoclonal IgG2b	Mouse (Protein G purified. PBS, 0.02% Sodium azide, pH: 7.40.)	-	Human	Epitope maps to residues 1-4 of human Aβ42 and Aβ40 (DAEF)	Reacts with the N-terminal end of Aβ (amino acids 1-4). Appears to detect monomeric, oligomeric, and fibrillar forms of Aβ. Greater sensitivity for Aβ42 than Aβ40. Does not cross react with holo-APP or APP-CTFs.	Confirmed available March 2015.
	MOAB-2 (6C3)	Cayman Chemical Cat# 11610	monoclonal IgG2b	Mouse (Purified IgG in PBS, pH 7.2, containing 50% glycerol, and 0.02% sodium azide)	-	Human	Epitope maps to residues 1-4 of human Aβ42 and Aβ40 (DAEF)	Reacts with the N-terminal end of Aβ (amino acids 1-4). Appears to detect monomeric, oligomeric, and fibrillar forms of Aβ. Greater sensitivity for Aβ42 than Aβ40. Does not cross react with holo-APP or APP-CTFs.	Confirmed available March 2015.
	MOAB-2	Kerafast Cat# EB2001	monoclonal IgG2b	Mouse (Protein G purified; hepes buffered saline, pH 7.4, 50% glycerol)	-	Human, Mouse, Rat	Epitope maps to residues 1-4 of human Aβ42 and Aβ40 (DAEF)	Reacts with the N-terminal end of Aβ (amino acids 1-4). Appears to detect monomeric, oligomeric, and fibrillar forms of Aβ. Greater sensitivity for Aβ42 than Aβ40. Does not cross react with holo-APP or APP-CTFs.	Confirmed available March 2015.
	MOAB-2 (6C3)	Millipore Cat# MABN254	monoclonal IgG2aλ	Mouse (Protein G purified; buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. )	-	Human	Epitope maps to residues 1-4 of human Aβ42 and Aβ40 (DAEF)	Reacts with the N-terminal end of Aβ (amino acids 1-4). Appears to detect monomeric, oligomeric, and fibrillar forms of Aβ. Greater sensitivity for Aβ42 than Aβ40. Does not cross react with holo-APP or APP-CTFs.	Confirmed available March 2015.
	MOAB-2	Novus Biologicals Cat# NBP-2-13075	monoclonal IgG2b	Mouse (Protein G purified; Tris-glycine buffer with 150mM NaCl and 0.05% Sodium Azide; pH 7.5 )	-	Human, Mouse, Rat	Epitope maps to residues 1-4 of human Aβ42 and Aβ40 (DAEF)	Reacts with the N-terminal end of Aβ (amino acids 1-4). Appears to detect monomeric, oligomeric, and fibrillar forms of Aβ. Greater sensitivity for Aβ42 than Aβ40. Does not cross react with holo-APP or APP-CTFs.	Confirmed available March 2015.
Iron Related From manufacturers (1)
	Ferroportin /SLC40A1	LifeSpan Biosciences, Inc.	polyclonal IgG	Rabbit (liquid, affinity purified, PBS, azide, glycerol)	-	Human	immunogen = synthetic peptide corresponding to N-terminal residues of human MTP1 (Metal transporter protein 1), conj. to KLH	detects ferroportin	-
Mitochondrial Proteins, Microglial Markers From manufacturers (1)
	Anti-PBR antibody (EPR5384)	Abcam Cat# ab109497	monoclonal IgG	Rabbit (Tissue culture supernatant. PBS 49 percent, sodium azide 0.01 percent, glycerol 50 percent, BSA 0.05 percent.)	-	Human, Mouse	A synthetic peptide corresponding to residues at the C-terminus of human peripheral benzodiazepine receptor (PBR)/translocator protein (TSPO).	This antibody recognizes PBR, also known as TSPO, a mitochondrial transporter that is upregulated in activated microglia.	Confirmed available December 2014.
Synucleins From labs (2)
	α-Synuclein	α-Synuclein SNL-1(Virginia Lee, University of Pennsylvania, CNDR, Philadelphia, PA)used in paper by Giasson, 1999	polyclonal	Rabbit	-	-	immunogen = synthetic peptides corresponding to amino acids 104-119 in α-syn		-
	α-Synuclein	α-Synuclein SNL-4(Virginia Lee, University of Pennsylvania, CNDR, Philadelphia, PA)used in paper by Giasson, 1999	polyclonal	Rabbit	-	-	immunogen = a synthetic peptide corresponding to residues 2-12 of α-synuclein		-
TAR DNA-binding protein /TDP-43 From manufacturers (1)
	Anti-phospho TDP-43 (ser409/410) (1D3)	Millipore Cat# MABN14	monoclonal IgG2ak	Rat (Purified in buffer containing 0.1 M Tris glycine with 0.05% sodium azide)	-	Human	Ovalbumin-conjugated linear peptide corresponding to human TDP-43 phosphorylated at serine 409 and 410.	This antibody recognizes human TDP-43 phosphorylated at serine 409 and 410.	Confirmed Oct 2014
Tau From labs (4)
	Tau (MC1)	Formerly available through Dr. Peter Davies. For updated information, see AlzAntibodies page linked in Note below.	monoclonal IgG1	Mouse	-	Human, Mouse	conformation dependent antibody (epitope within aa 312-322)	reactivity depends on both the N terminus (amino acids 7–9), and an amino acid sequence of tau (amino acids 313–322) in the third microtubule binding domain. Recognizes neurofibrillary tangles but does not react with FAC1	-
	Tau (Alz50)	Formerly available through Dr. Peter Davies. For updated information, see AlzAntibodies page linked in Note below.	monoclonal IgM	Mouse	-	-	Raised against human basal forebrain homogenate. Epitope subsequently determined to include amino acids 2-10 and 312-342 of tau.	Recognizes a misfolded conformation of tau. 68 kDa Tau. Stains neuronal components of AD brain specimens but not normal brain specimens.	-
	Tau phos Ser396/Ser404 (PHF-1)	Formerly available through Dr. Peter Davies. For updated information, see AlzAntibodies page linked in Note below.	monoclonal IgG1	Mouse	-	Human	Immunogen: paired helical filaments of tau. Epitope: around serine-396 and serine-404 phosphorylated sites.	-	-
	Tau phos Ser202 (CP13)	Formerly available through Dr. Peter Davies. For updated information, see AlzAntibodies page linked in Note below.	monoclonal IgG2b	Mouse	-	Human	epitope around phospho-serine 202	Detects tau phosphorylated at serine-202.	-
Tau From manufacturers (6)
	Tau (HT-7)	Innogenetics	monoclonal	Mouse	-	Bovine, Human	immunogen = purified human tau; (epitope within aa 159-163)	phosphorylated and non phosphorylated tau	-
	Tau phos Thr181 (AT270)	Innogenetics	monoclonal IgG1κ	Mouse (liquid, sterile filtered, PBS, no preservative, affinity purified)	-	Human	immunogen = human tau40, aa. around phospho. Thr 181	specific for tau phospho at Thr 181; as PHF-tau, tangles and neurofilaments; weak cross with normal tau;	-
	Tau Ag	Innogenetics	kit	Mouse (solid-phase enzymeimmunoassay, uses monoclonal AT120 for capture, HT7 and BT2 for incubation. Streptavidin detection of the antibodies.)	-	Human	-	tau in cerebrospinal fluid	-
	Tau (248E5)	Synaptic Systems Cat# 314011	monoclonal IgG2a	(Purified IgG, lyophilized. Azide was added before lyophilization. Unconjugated.)	-	Human, Mouse, Rat	Recombinant mouse tau (amino acids 3 - 214)	The antibody binds phosphorylated and non-phosphorylated tau proteins.	Confirmed available March 2014
	Tau	Synaptic Systems Cat# 314 002	polyclonal	Rabbit (antiserum, lyophilized. )	-	Human, Mouse, Rat	Recombinant mouse tau (amino acids 3 - 214).	The antibody binds phosphorylated and non-phosphorylated tau proteins.	Confirmed available March 2014
	Tau (AT8)	Pierce Thermo Scientific Cat#  MN-1020	monoclonal IgG1κ	Mouse (Protein A affinity purified, PBS, no preservative)	-	Baboon, Human, Rabbit, Hamster, Avian (various), Drosophila	immunogen = partially purified human paired helical filament tau.	Recognizes tau protein phosphorylated at both serine 202 (Ser202) and threonine 205 (Thr205). Does not cross-react with unphosphorylated forms of tau.	Confirmed available April 2015.
γ-secretase/ Presenilins From labs (1)
	PS1, C-terminal	4627Dr. Dennis Selkoe,Harvard Univ. Medical School, Boston, MAReference: Sato, 2007	polyclonal	Rabbit	-	Human, Hamster, Mouse	immunogen = synthetic peptide corresp. to the C-terminal 10 amino acids of PS1 (aa 457-467) Paper	extreme C-terminal PS1, and PS1 CTF	-