Clonality: polyclonal
Host: Rabbit
Source: anti-APP C8
(Dr. Dennis Selkoe,
Harvard Univ. Medical School, Boston, MA)
References:
Davis, 2010
Senechal, 2008
Wang, 2007
Reactivity:
Reacts in: Mammal (various), Human

Immunogen/Epitope

residues 676-695, comprising the 20 C-terminal amino acids of human βAPP cytoplasmic domain.
Paper, Selkoe et al.

Specificity

recognizes full length APP and all CTFs

Comments / Questions

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References

Paper Citations

1. Davis AA, Fritz JJ, Wess J, Lah JJ, Levey AI. Deletion of M1 muscarinic acetylcholine receptors increases amyloid pathology in vitro and in vivo. J Neurosci. 2010 Mar 24;30(12):4190-6. PubMed.
2. Senechal Y, Kelly PH, Dev KK. Amyloid precursor protein knockout mice show age-dependent deficits in passive avoidance learning. Behav Brain Res. 2008 Jan 10;186(1):126-32. PubMed.
3. Wang J, Ho L, Chen L, Zhao Z, Zhao W, Qian X, Humala N, Seror I, Bartholomew S, Rosendorff C, Pasinetti GM. Valsartan lowers brain beta-amyloid protein levels and improves spatial learning in a mouse model of Alzheimer disease. J Clin Invest. 2007 Nov;117(11):3393-402. PubMed.

Other Citations

1. Dr. Dennis Selkoe

External Citations

1. Paper

Further Reading

No Available Further Reading