Antibody

Tau (HT-7)

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Clonality: monoclonal
Host: Mouse
Source: Innogenetics
cat# BR-001
distributed by Autogen Bioclear as 90222
References:
Siderowf, 2010
Clinton, 2010
Ueno, 2007
Oddo, 2005
Guo, 2006
Caccamo, 2006
Boekhoorn, 2006
Reactivity:
Reacts in: Bovine, Human
not rat

Immunogen/Epitope

immunogen = purified human tau; (epitope within aa 159-163)

Specificity

phosphorylated and non phosphorylated tau

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References

Paper Citations

  1. Siderowf A, Xie SX, Hurtig H, Weintraub D, Duda J, Chen-Plotkin A, Shaw LM, Van Deerlin V, Trojanowski JQ, Clark C. CSF amyloid {beta} 1-42 predicts cognitive decline in Parkinson disease. Neurology. 2010 Sep 21;75(12):1055-61. PubMed.
  2. Clinton LK, Blurton-Jones M, Myczek K, Trojanowski JQ, Laferla FM. Synergistic Interactions between Abeta, tau, and alpha-synuclein: acceleration of neuropathology and cognitive decline. J Neurosci. 2010 May 26;30(21):7281-9. PubMed.
  3. Ueno H, Murayama O, Maeda S, Sahara N, Park JM, Murayama M, Sanda A, Iwahashi K, Matsuda M, Takashima A. Novel conformation-sensitive antibodies specific to three- and four-repeat tau. Biochem Biophys Res Commun. 2007 Jun 29;358(2):602-7. PubMed.
  4. Oddo S, Caccamo A, Green KN, Liang K, Tran L, Chen Y, Leslie FM, Laferla FM. Chronic nicotine administration exacerbates tau pathology in a transgenic model of Alzheimer's disease. Proc Natl Acad Sci U S A. 2005 Feb 22;102(8):3046-51. PubMed.
  5. Williams DR, Watt HC, Lees AJ. Predictors of falls and fractures in bradykinetic rigid syndromes: a retrospective study. J Neurol Neurosurg Psychiatry. 2006 Apr;77(4):468-73. PubMed.
  6. Caccamo A, Oddo S, Billings LM, Green KN, Martinez-Coria H, Fisher A, Laferla FM. M1 receptors play a central role in modulating AD-like pathology in transgenic mice. Neuron. 2006 Mar 2;49(5):671-82. PubMed.
  7. Boekhoorn K, Terwel D, Biemans B, Borghgraef P, Wiegert O, Ramakers GJ, de Vos K, Krugers H, Tomiyama T, Mori H, Joels M, Van Leuven F, Lucassen PJ. Improved long-term potentiation and memory in young tau-P301L transgenic mice before onset of hyperphosphorylation and tauopathy. J Neurosci. 2006 Mar 29;26(13):3514-23. PubMed.

Further Reading

No Available Further Reading