Clonality: polyclonal
Host: Rabbit
Source: R1736
(Dr. Dennis Selkoe,
Harvard Univ. Medical School, Boston, MA)
Reference: Maier, 2008,
Formulation: antiserum
Reactivity:
Reacts in: Rodent (various), Human

Immunogen/Epitope

immunogen = synthetic peptide of amino acids 595–611 of APP

Specificity

APP epitope corresponds to positions -2 to +15 of human Abeta, and it presents 90% (15 out of 17 amino acids) of sequence homology with the hamster sequence which is identical to other rodents such as mouse

Comments / Questions

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References

Paper Citations

1. Maier M, Peng Y, Jiang L, Seabrook TJ, Carroll MC, Lemere CA. Complement C3 deficiency leads to accelerated amyloid beta plaque deposition and neurodegeneration and modulation of the microglia/macrophage phenotype in amyloid precursor protein transgenic mice. J Neurosci. 2008 Jun 18;28(25):6333-41. PubMed.

Other Citations

1. Dr. Dennis Selkoe

Further Reading

No Available Further Reading