Hiroshi Mori on The 118-135 peptide of the human prion protein forms amyloid fibrils and induces liposome fusion.

COMMENT Although prion is different from AD amyloid protein, its aggregation mechanism is undoubtedly interesting. Any data on protein-chemical process is welcome for understanding other amyloids. 0 mori

Hiroshi Mori on Diffusible, nonfibrillar ligands derived from Abeta1-42 are potent central nervous system neurotoxins.

COMMENT This paper shows some relationship between ADDLs and Fyn function in amyloid-derived toxic reaction. It may contribute to the molecular analysis of apoptosis in AD. 0 mori

Hiroshi Mori on Inhibition of Alzheimer beta-fibrillogenesis by melatonin.

COMMENT This study is a new experiment that may be interesting. It might be just a radical scavenger but melatonin is interesting because it crosses BB-barrier. 0 mori

Hiroshi Mori on Interaction of Alzheimer beta-amyloid peptide(1-40) with lipid membranes.

COMMENT A-beta1-40 is one of cerebral amyloid species and believed to be associated with APOE allele e4. Any information for an interaction of this amyloid species with other molecules is welcome to understand AD pathogenesis. 0 mori

Hiroshi Mori on Proteolytic fragments of the Alzheimer's disease associated presenilins-1 and -2 are phosphorylated in vivo by distinct cellular mechanisms.

COMMENT Phosphorylation could be a factor in regulating the different functions of the two presenilin molecules. 0 mori

Paul Coleman on Hippocampal atrophy and apolipoprotein E genotype are independently associated with Alzheimer's disease.

COMMENT This is consistent with other studies suggesting the significance of APO E may not be through an action on the neuropil. 0 Paul_Coleman

Hiroshi Mori on Apolipoprotein E and Tau phosphorylation in human neuroblastoma cells.

COMMENT It is noteworthy that tau phosphorylation is independent of apoE allelic function. 0 mori

Hiroshi Mori on Melatonin prevents beta-amyloid-induced lipid peroxidation.

COMMENT Free radicals are potent factors to induce neruopathogenesis of AD and should be examined from variable views. This reports on multiple functions for melatonin to attenuate radical oxidation reaction. 0 mori

Paul Coleman on Role of sphingolipid-mediated cell death in neurodegenerative diseases.

COMMENT The role of lipid-dependent signaling systems in apoptosis of a variety of systems has been known for some time. Although this review may not contain new information it can serve the purpose of emphasizing the potential importance of this signalling pathw

Paul Coleman on Neuropathology of three clinical cases prospectively diagnosed as dementia with Lewy bodies.

COMMENT A contribution to the difficult problem of diagnosis of LBD. 0 Paul_Coleman

Edward Koo on Familial Danish dementia: a novel form of cerebral amyloidosis associated with deposition of both amyloid-Dan and amyloid-beta.

COMMENT More non-abeta related amyloid pathology. This extends the interesting British dementia reported several years ago. 0 edkoo

Zaven Khachaturian on Secreted glypican binds to the amyloid precursor protein of Alzheimer's disease (APP) and inhibits APP-induced neurite outgrowth.

COMMENT This paper is important because it provides further evidence for the neuroprotective role of APP. Mechanisms of neurite outgrowth are important areas of research in developing treatments for AD. 0 zaven_khachaturian

Benjamin Wolozin on SNPing away at complex diseases: analysis of single-nucleotide polymorphisms around APOE in Alzheimer disease.

COMMENT New associations between ApoE and AD 0 bwolozin

Edward Koo on Preimplantation diagnosis for early-onset Alzheimer disease caused by V717L mutation.

COMMENT Obviously this technology has been around and we know it will work. But this is the first time this has been used for select for embryo free of one genetic disease. Start of a slippery slope? 0 edkoo

Hiroshi Mori on Apolipoprotein E genotype does not affect the age of onset of dementia in families with defined tau mutations.

COMMENT The paper tells something about the molecular mechanism for ApoE function by evidence that ApoE influences development of dementia rather than onset time. 0 mori