John Hardy on Familial Danish dementia: a novel form of cerebral amyloidosis associated with deposition of both amyloid-Dan and amyloid-beta.

COMMENT This, together with the equally unfortunately named, British dementia, are extremely informative "models" for AD. 0 J.Hardy

Richard Mayeux on Is the risk of developing Alzheimer's disease greater for women than for men?

COMMENT This work provides evidence to suggest that rates of Alzheimer’s disease are similar in men and women. 0 rpm2

Paul Coleman on Neuropathological assessment of the lesions of significance in vascular dementia.

COMMENT An important contribution to a still murky area. 0 Paul_Coleman

Gerry Fischbach on Inhibition of protein phosphatase-2B (calcineurin) activity towards Alzheimer abnormally phosphorylated tau by neuroleptics.

COMMENT This seems like a coincidental, uninteresting finding… 0 gf224

Hiroshi Mori on The level of cerebrospinal fluid tau correlates with neurofibrillary tangles in Alzheimer's disease.

COMMENT To further the search for concrete diagnostic tools, any study is essentially welcome. This study is one of such trials. 0 mori

Benjamin Wolozin on Effects of environmental enrichment on gene expression in the brain.

COMMENT Interesting new approach. 0 bwolozin

Carl Cotman on Presenilin-1 polymorphism in patients with Alzheimer's disease, vascular dementia and alcohol-associated dementia in Japanese population.

COMMENT A very interesting genetics paper 0 cwcotman

Benjamin Wolozin on Two novel point mutations of mitochondrial tRNA genes in histologically confirmed Parkinson disease.

COMMENT I have no idea what this means, but since the risk factors for PD are unknown, this is quite interesting. 0 bwolozin

Benjamin Wolozin on Designing drugs to stop the formation of prion aggregates and other amyloids.

COMMENT Potential useful information for those developing therapeutics. 0 bwolozin

Hiroshi Mori on Opposite roles of apolipoprotein E in normal brains and in Alzheimer's disease.

COMMENT There is a little evidence showing in vivo difference in apoE function between normal and AD brains. The present article may contribute to such a study. 0 mori

Gerry Fischbach on Localization of transglutaminase in hippocampal neurons: implications for Alzheimer's disease.

COMMENT Potentially very interesting because a plausible mechanism is implied. The specificity of the antibodies when applied to neural tissue- not just to purifier enzyme- should be mentioned. If the antibody is specific, this is an interesting paper 0 gf224

Hiroshi Mori on Acute application of human amylin, unlike beta-amyloid peptides, kills undifferentiated PC12 cells by apoptosis.

COMMENT The relationship between toxic activity and structure of amyloid peptide is interesting. Amylin may be a clue to give further information to understand Abeta story in AD. 0 mori

Hiroshi Mori on Par-4 is a mediator of neuronal degeneration associated with the pathogenesis of Alzheimer disease.

COMMENT It is very interesting how and when and where prostate apoptosis response-4 (Par-4) is altered in AD brains. 0 mori

John Olney on Protein nitration in Parkinson's disease.

COMMENT Good et al. provide interesting evidence that oxidative products related to protein nitration are deposited in Lewy bodies in the brains of patients with Parkinson's disease. This is a well performed study which is directly relevant to neurodegenerat

Hiroshi Mori on Alpha-2 macroglobulin is genetically associated with Alzheimer disease.

COMMENT A2M is claimed to be associated with AD using some AD cases. It is rational from the considerable amount of evidence accumulated by neuropathologists. The story is not new but its impact is significant. 0 mori