11505 RESULTS
COMMENT This very interesting article presents important knowledge on how the apoE isoforms affect brain function, memory, and memory dysfunction. The functional aspect is a major plus, as it extends the simplistic consideration of seeing the role of apoE in Alzh
COMMENT This is a very good overview of the use of psychophysics to probe cognitive tasks that might be sensitive to early changes in AD. The finding that specific aspects of visual attention vary as a function of apoE genotype is especially intriguing. The mecha
COMMENT The three papers examine the important issue of whether subtle changes in psychometric measures can provide predictors as early as 3-5 years before patients develop an "end point" such as mild dementia or mild cognitive impairment (MCI). Many st
COMMENT The epidemiology supporting an association of chronic and early NSAID use with reduced risk for AD is consistent enough to take seriously. Results from the recent Rotterdam and Cache County studies, as well as many others, suggest that risk for AD can be
COMMENT The main purpose of our Neurology study was to determine tolerability in AD of nimesulide, a NSAID preferentially inhibiting cyclooxygenase (COX)-2 but also, to a lesser degree, COX-1. The study was designed to test if nimesulide is suitable in chronic tr
COMMENT Its very nice to see the beginnings of a test for the King & Wilson 1975 idea, (especially for both RNA and protein). There's still a long way to go to dissect out the quantitative effects on the alternative splice forms for the various mRNAs in
COMMENT "A central issue in medicine is the grouping of disorders on the basis of their etiology, yet one common clinico-pathologic feature of diseases does not indicate a common etiology. Therefore, from a nosological point of view, Alzheimer's disease
COMMENT The remarkable finding described by Dodart et al. in Nature Neuroscience adds an important page to the evolving story of Aβ toxicity in Alzheimer's disease. It builds on two related discoveries. First, thanks to the pioneering work of Dale Schenk and
COMMENT "The findings by Dodart and colleagues are very interesting. However, as Steven Paul points out in the Q and A session on this website, it remains to be seen if a similar effect will be observed in other transgenic AβPP mouse models and eventually in
COMMENT Our study identifies a specific form of naturally produced human amyloid beta protein, namely stable low-n oligomers, as directly interrupting a key correlate of memory and learning in a living animal. Previous research by many scientists had linked Ab in
COMMENT On Insulin and Neuronal Plasticity Functionally, synaptic plasticity forms the most important site of neuronal plasticiy. Recent evidence suggests that both activity and plasticity of synapses depend on biochemical stimuli induced by the expression of the
COMMENT This is an interesting manuscript that asks whether two different classes of anti-parkinsonian drugs (the dopamine precursor L-DOPA, and the D2/D3 dopamine receptor agonist pramipexole) differentially affect dopamine neuron viability over the course of 4
COMMENT These two articles rightly emphasize that RNA splicing measures are extremely important and poorly served by array methods so far. However, there are some problems with using exon junctions for array assays as they propose. (1) Many alternatively spliced
COMMENT Use of viral vector for targeting transgene expression in a region- and time-specific manner was first demonstrated to model a neurodegenerative disorder, namely trinucleotide repeat disease, by Fred Gage's lab (Senut et al., 2000). This approach off
COMMENT I believe the most important aspect of our study is that we describe a new approach to study protein dysfunction in appropriate animal models with a strong basis in morphological, biochemical as well as behavioral assessments. Our model offers numerous ad
