11505 RESULTS
COMMENT While the germline transgenic approach is the gold standard for studying gene function in the brain, it is also labor-intensive, expensive, and requires long periods of time to screen and raise the animals. We have adopted an alternative somatic transgeni
COMMENT These data provide further support for the peripheral sink hypothesis, and suggest that the blood-brain-barrier may be a fine sieve for brain Ab that is substantially limited by plasma Aβ concentrations. If these findings can be meaningfully replicated am
COMMENT These are very interesting studies. The purpose of these studies might be making pluripotent cells from adult stem cells by fusing them with embryonic stem cells. Unfortunately, tetraploid cells made tumors in Terada's study, which we expected. Smith
COMMENT trials of traditional NSAIDs. Nevertheless, there are many comments in the literature expressing doubt
COMMENT Jick et al., 2000; Wolozin et al., 2000). On the other hand, the literature linking cholesterol and cognitive decline is less clear, because some studies have suggested that ApoE4, rather than cholesterol, is more strongly associated with cognitive declin
COMMENT Dave Holtzman nicely summarizes some of the principal findings of the presenters. In general, there was further experimental support for the conclusion that several different immunological approaches to clearing brain Aβ are effective in mouse models. Alt
COMMENT In humans, a substantial body of evidence suggests NSAIDs confer some protection from AD. Importantly, these clinical studies on NSAIDs shed no light on whether NSAIDS could have therapeutic efficacy in patients who already have AD. In addition, it is gen
COMMENT in his comments that microglial activation is a beneficial phenomenon up to the level where host
COMMENT Contrary to assumptions that mutant superoxide dismutase (mSOD) causes ALS via peroxynitrite-mediated oxidative injury, Subramaniam et al. provide compelling evidence that mSOD toxicity is not due to the copper-dependent catalytic activity of peroxynitrit
COMMENT This paper presents data suggesting that chronic use of a NO-releasing NSAID attenuates Aβ plaque load in an animal model of Aβ neuropathology. Additionally, the data indicate that the efficacy of this NO-releasing NSAID was mediated by microglia activati
COMMENT The paper by Subramaniam et al. demonstrates for the first time that chaperone-mediated copper loading is not required for mutant SOD protein to produce ALS-like disease. Mutant SOD protein-mediated motor neuron disease was not affected in the absence of
COMMENT The new genome screen on Alzheimer's and Parkinson's diseases reported by Pericak-Vance et al. is a very interesting and provocative paper using age-at-onset (AAO) as a quantitative trait to search for novel AD and PD genes. The most interesting
COMMENT Authors' Reply We appreciate Dr. Beach's comment on our publication, and his comments
COMMENT It appears that expression of Cox-1 and 2 varies with species, dose, route and type of insult. Neurons, microglia, astrocytes and also the peripheral macrophages that migrate into the brain following injury can all express Cox-2. The expression of Cox-1 h
COMMENT Our published work indicates that (1) COX-2 expression in the AD brain tissues involves blood-derived macrophages, not neurons; (2) macrophages are infiltrating the neuritic plaques and phagocytizing amyloid-beta. COX-2 activation in the brain appears to
