Hiroshi Mori on Alzheimer's amyloid precursor protein alpha-secretase is inhibited by hydroxamic acid-based zinc metalloprotease inhibitors: similarities to the angiotensin converting enzyme secretase.

COMMENT This paper may be important for the new lipid complex which is invovled in ApoE function of forming AD pathogenesis. 0 mori

Hiroshi Mori on The amyloid beta protein induces oxidative damage of mitochondrial DNA.

COMMENT This study is interesting because this shows amyloid toxicity targets mitochondrial DNA but not chormosmal DNA. 0 mori

Hiroshi Mori on Astrocytes containing amyloid beta-protein (Abeta)-positive granules are associated with Abeta40-positive diffuse plaques in the aged human brain.

COMMENT It is significant to look cytoplasmic Ab deposition or Ab-like accumulation in glial cells. It may be linked to the next important issue of clearance of cerebral amyloid. 0 mori

Hiroshi Mori on Specific neurochemical derangements of brain projecting neurons in apolipoprotein E-deficient mice.

COMMENT Apo E KO mice is one of interesting Tg animals. The detailed information on this mouse must give useful knowlege to understand AD pathogenesis. 0 mori

Edward Koo on Lipid metabolism parameters in patients with Alzheimer's disease and their first degree relatives.

COMMENT Results from this epidemiological study are unexpected. Based on accumulating experimental data, one would have predicted the opposite outcome. 0 edkoo

Paul Coleman on Presenilin 1 associates with glycogen synthase kinase-3beta and its substrate tau.

COMMENT This ability of PS 1 to link GSK-3-beta with tau may be particularly important in view of the role that GSK-3-beta appears to play in phosphorylating tau. 0 Paul_Coleman

Paul Coleman on Apolipoprotein E4, cholinergic integrity and the pharmacogenetics of Alzheimer's disease.

COMMENT This paper proposes that the relationship between apo E and AD revolves around their statement that 'During dendritic remodelling and synaptogenesis, neurons progressively repress the synthesis of cholesterol in favor of cholesterol internalization t

Hiroshi Mori on Neuropathological assessment of the lesions of significance in vascular dementia.

COMMENT The precise guidline or suggestion should be further studied because neuropathology is unquestionably the most important and respected field in AD. Any discussion on neuropathology should be referred to widely in other fields of investigation. 0 mori

Hiroshi Mori on Possible role of tau protein kinases in pathogenesis of Alzheimer's disease.

COMMENT It is difficult to separate tau pathology from AD. This means that tau is not exclusively specific to AD but deeply involved in cell death in AD. Any data on phosphorylation or kinase should be examined more. 0 mori

Benjamin Wolozin on Parkinson disease neuropathology: later-developing dementia and loss of the levodopa response.

COMMENT As we begin to categorize and understand the variations in neurodegenerative diseases, the information will have increasing implications for therapy. This paper provides an important example describing a neurodegenerative variant of PD that might account

Hiroshi Mori on A novel neurological phenotype in mice lacking mitochondrial manganese superoxide dismutase.

COMMENT Reactive oxygen species (ROS) have been implicated in a wide range of degenerative processes including amyotrophic lateral sclerosis, ischemic heart disease, Alzheimer disease, Parkinson disease and aging(1-5). The present study strongly suggests the sign

Hiroshi Mori on The beta-amyloid precursor protein of Alzheimer's disease enhances neuron viability and modulates neuronal polarity.

COMMENT APP must be studied both for its role in pathogenesis of AD and basic housekeeping molecule for neurons. The authors try to clarify the latter purpose using APP-knockout mice. 0 mori

Hiroshi Mori on Amyloid plaques in Guam amyotrophic lateral sclerosis/parkinsonism-dementia complex contain species of A beta similar to those found in the amyloid plaques of Alzheimer's disease and pathological aging.

COMMENT ALS/PDC is another disease bearing senile plaques and interesting to compare with those in AD brains. 0 mori

John Olney on Reactive oxygen species and the neurodegenerative disorders.

COMMENT This is a review article discussing the potential involvement of reactive oxygen species in neurodegenerative disorders. It does not present any new information and it probably does not mention the fact that reactive oxygen species have been around for ab

Paul Coleman on Effect of Alzheimer's brain extracts on dynein immunoreactivity in PC12 cells.

COMMENT An important study. I would have liked to have seen this also done in a double IHC study to relate dynein IR to disease status of single neurons. 0 Paul_Coleman