Hiroshi Mori on Free radicals and superoxide dismutase in blood of patients with Alzheimer's disease and vascular dementia.

COMMENT Free radicals and SOD are interesting to understand AD etiology. The present study addresses the quantitative and careful examination on patients and is important. Further experiments including experimental condition should be done. 0 mori

Elliott Mufson on Glial-neuronal interactions in Alzheimer disease: progressive association of IL-1alpha+ microglia and S100beta+ astrocytes with neurofibrillary tangle stages.

COMMENT Interesting 0 emufson

Benjamin Wolozin on Interaction of human alpha-Synuclein and Parkinson's disease variants with phospholipids. Structural analysis using site-directed mutagenesis.

COMMENT Important contribution to understanding synuclein biology. 0 bwolozin

Nikolaos K. Robakis on Inhibition of platelet activation by the Alzheimer's disease amyloid precursor protein.

COMMENT I find this very interesting because it also suggests an APP role in cell adhesion (inhibits platelet aggregation) and indicates a role for the cysteine-rich region of APP. 0 nikos.robakis

Hiroshi Mori on The regulation of phosphorylation of tau in SY5Y neuroblastoma cells: the role of protein phosphatases.

COMMENT Phosphorylation is regulated by kinases and phosphatases. SY5Y cells are interesting because of neuronal derivative line and worth examining for kinase activity and phosphorylation. Such results must be useful for the treatment of the drug to control tau

Hiroshi Mori on Co-localization of truncated tau and DNA fragmentation in Alzheimer's disease neurones.

COMMENT The double occurrence of protein in AD tissues are well documented but it is rare to show the occurrence of two different components of the protein such as tau and the nucleic acid. 0 mori

John Olney on High constitutive NF-kappaB activity mediates resistance to oxidative stress in neuronal cells.

COMMENT Lezuoualch et al report complicated evidence suggesting that high NF-Kappa-B activity is associated with resistance to oxidative stress in cultured "sympathetic precursor-like cells". They conclude that their cell culture model may help identify

Paul Coleman on Mitochondrial genome lesions in the pathogenesis of sporadic Alzheimer's disease.

COMMENT Apparently a review. 0 Paul_Coleman

Peter Davies on First Alzheimer's diagnosis confirmed.

COMMENT Alzheimer was right all the time! 0 peter.davies

Hiroshi Mori on Cytoskeletal alterations in the aged human neurohypophysis.

COMMENT Pathological changes in AD brain must be studied from different viewpoints. This study may provide us information on another important pathological alteration. 0 mori

Hiroshi Mori on Isolation and characterization of novel presenilin binding protein.

COMMENT It is interesting to consider the possible functions of the binding proteins associated with PS. This paper may be one of such clues. 0 mori

Hiroshi Mori on No association of presenilin-1 intronic polymorphism and Alzheimer's disease in Australia.

COMMENT This reports essentially the negative result but is important for understanding presenilin-1 function. We should be aware of the large amount of sporadic cases besides familial cases. 0 mori

George Perry on Alcohol consumption and risk of dementia: the Rotterdam Study.

COMMENT etiology of Alzheimer disease.- comment by George Perry and Mark A. Smith 0 george.perry Alcohol

Hiroshi Mori on Recombinant human amyloid precursor-like protein 2 (APLP2) expressed in the yeast Pichia pastoris can stimulate neurite outgrowth.

COMMENT The experimental system sounds to be interesting to pick up APP function. 0 mori

Elliott Mufson on Cerebral metabolic differences in Parkinson's and Alzheimer's diseases matched for dementia severity.

COMMENT Interesting. 0 emufson