Perrin RJ, Woods WS, Clayton DF, George JM. Interaction of human alpha-Synuclein and Parkinson's disease variants with phospholipids. Structural analysis using site-directed mutagenesis. J Biol Chem. 2000 Nov 3;275(44):34393-8. PubMed.

Comments

- Hiroshi Mori
  Osaka City University Medical School
- Posted: 21 May 2002
It is no doubt to see an interaction of alpha -Syn with the lipid fraction because alpha-Syn has been identified as a hydrophobic synaptic component. The urgent issue to know may be in the next step for alpha-Syn.

View all comments by Hiroshi Mori

- Benjamin Wolozin
  Boston University School of Medicine
- Posted: 21 May 2002
Important contribution to understanding synuclein biology.

View all comments by Benjamin Wolozin

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