Carl Cotman on An ApoE-Abeta inhibition complex in Abeta fibril extension.

COMMENT Helps clarify a very complex literature 0 cwcotman

Edward Koo on Head circumference and incident Alzheimer's disease: modification by apolipoprotein E.

COMMENT Oh oh, what, my head size? Is there good data that head size actually equals more neurons if this has to do with brain reserve? 0 edkoo

Hiroshi Mori on Alzheimer's alpha-secretase may be a calcium-dependent protease.

COMMENT Evidence of any information for secretase is valid in understanding amyloid depositions in AD. Especially this is a new candidate for alpha-secretase. 0 mori

Benjamin Wolozin on Tau-66: evidence for a novel tau conformation in Alzheimer's disease.

COMMENT A potentially valuable new probe for studying tau pathology. 0 bwolozin

Hiroshi Mori on Relationship between apolipoprotein E and the amyloid deposits and dystrophic neurites of Alzheimer's disease.

COMMENT This study focuses on the effect of APOE on amyloid deposition particularly regarding regional distibution. Hence this contains a neuropathologically important finding. 0 mori

Benjamin Wolozin on Endogenous beta-amyloid production in presenilin-deficient embryonic mouse fibroblasts.

COMMENT This is an interesting paper that flies in the face of much research on presenilins. Dr. Checler's group produces data showing that elimination of presenilin 1 and 2 does not inhibit production of Abeta, but does inhibit cleavage of NOTCH to produce

Nikolaos K. Robakis on Cholesterol depletion inhibits the generation of beta-amyloid in hippocampal neurons.

COMMENT This is an interesting paper as it may explain the role of ApoE in Ab production as well as the mechanism of g-secretase cleavage. The problem is that no correlation has been demonstrated between cholesterol levels and AD. 0 nikos.robakis

John Olney on Effects of aging and dementia on the levels of thiobarbituric-acid-reactive products stimulated by L-glutamic acid in human autopsy and biopsy brain tissue.

COMMENT It is not clear what significance there might be to thiobarbituric acid-reactive products in brain tissue, whether stimulated by glutamic acid or unstimulated. The authors did not seem to have found interesting differences between normal aging and Alzheim

Paul Coleman on Impaired proteolytic processing of presenilin-1 in chromosome 14-linked familial Alzheimer's disease patient lymphocytes.

COMMENT Although the abstract and title indicate there is some AD/control difference, it is not clear how much overlap there may be between the two groups. The nature of the control patients is not apparent from the abstract. 0 Paul_Coleman

Hiroshi Mori on Apolipoprotein E phenotype is not related to late-life depression in a population-based sample.

COMMENT The molecular mechanism of APOE e4 is not determined yet. Moreover, little information is available to understand the physiological function of APOE in brain tissue. Different studies from amyloid or tau must be welcome. 0 mori

Hiroshi Mori on Crystal structure of the N-terminal, growth factor-like domain of Alzheimer amyloid precursor protein.

COMMENT Crystalization of N-domain of APP is supposed to provide the seminal elucidation for APP growth activity. 0 mori

Benjamin Wolozin on Low cholesterol stimulates the nonamyloidogenic pathway by its effect on the alpha -secretase ADAM 10.

COMMENT Modulating cholesterol increasing appears to be a viable method for modulating Ab production, and this article provides more information on this type of modulation. 0 bwolozin

Hiroshi Mori on Utility of the apolipoprotein E genotype in the diagnosis of Alzheimer's disease. Alzheimer's Disease Centers Consortium on Apolipoprotein E and Alzheimer's Disease.

COMMENT This study using about 2,000 cases concludes that ApoE allele e4 is a risk factor and not a determinant factor of the disease. It, however, suggests a potent increase of the diagnosis if other factors are added for consideration. 0 mori

Paul Coleman on Mutation in the alpha-synuclein gene and sporadic Parkinson's disease, Alzheimer's disease, and dementia with lewy bodies.

COMMENT 'Exploration of the... mutation of the alpha-synuclein gene as that in familial PD (Ala53Thr)... in sporadic PD, DLB, and AD revealed the mutation in none of the samples of 329 cases and 230 controls examined, suggesting that this mutation is not inv

Benjamin Wolozin on Alzheimer's disease: model behaviour.

COMMENT Models of AD are clearly important. 0 bwolozin