Simons M, Keller P, De Strooper B, Beyreuther K, Dotti CG, Simons K.
Cholesterol depletion inhibits the generation of beta-amyloid in hippocampal neurons.
Proc Natl Acad Sci U S A. 1998 May 26;95(11):6460-4.
PubMed.
This is an interesting paper as it may explain the role of ApoE in Ab production as well as the mechanism of g-secretase cleavage. The problem is that no correlation has been demonstrated between cholesterol levels and AD.
Comments
Osaka City University Medical School
This paper shows that cholesterol is a key for APP metabolism to produce A-beta. This may be relevant to the function of ApoE.
Mount Sinai School of Medicine, NYU
This is an interesting paper as it may explain the role of ApoE in Ab production as well as the mechanism of g-secretase cleavage. The problem is that no correlation has been demonstrated between cholesterol levels and AD.
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