Apaydin H, Ahlskog JE, Parisi JE, Boeve BF, Dickson DW.
Parkinson disease neuropathology: later-developing dementia and loss of the levodopa response.
Arch Neurol. 2002 Jan;59(1):102-12.
PubMed.
As we begin to categorize and understand the variations in neurodegenerative diseases, the information will have increasing implications for therapy. This paper provides an important example describing a neurodegenerative variant of PD that might account for the loss of Levodopa responsiveness. This provides an impetus to clinicians to identify treatments that can benefit such subclasses of patients.
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Boston University School of Medicine
As we begin to categorize and understand the variations in neurodegenerative diseases, the information will have increasing implications for therapy. This paper provides an important example describing a neurodegenerative variant of PD that might account for the loss of Levodopa responsiveness. This provides an impetus to clinicians to identify treatments that can benefit such subclasses of patients.
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