Hiroshi Mori on Decreased beta-amyloid1-42 in cerebrospinal fluid of patients with Creutzfeldt-Jakob disease.

COMMENT It is an important finding that decreased Abeta42 is not only specific to AD but also to CJD. This leads us to have a simple question [whether this is also the case in] other neurodegenerative disorders. 0 mori

Paul Coleman on Reduction of O-linked N-acetylglucosamine-modified assembly protein-3 in Alzheimer's disease.

COMMENT In the abstract the authors comment that "The number and levels of O-GlcNAc-containing

Paul Coleman on Neurofilament protein levels in CSF are increased in dementia.

COMMENT But these levels apparently do not differentiate vascular dementia, FTD and AD. 0 Paul_Coleman

Hiroshi Mori on How to cope with Alzheimer's disease?

COMMENT He documented the present clinical aspect of AD in Japan and suggests the coming phase of the disease. 0 mori

Hiroshi Mori on alpha-Synuclein membrane interactions and lipid specificity.

COMMENT It is no doubt to see an interaction of alpha-Syn with the lipid fraction because alpha-Syn has been identified as a hydrophobic synaptic component. The urgent issue to know may be in the next step for alpha-Syn. 0 mori

John Olney on Alternative splicing of the glutamate transporter EAAT2 (GLT-1).

COMMENT While they mention that glutamate transporters may play a role in neurodegenerative diseases, this abstract does not present any evidence relating their novel transcripts to disease mechanisms. They are simply reporting that they have cloned these transcr

Nikolaos K. Robakis on Overexpression in neurons of human presenilin-1 or a presenilin-1 familial Alzheimer disease mutant does not enhance apoptosis.

COMMENT It is important to clarify the issue of PS1 involvement in apotosis, especially since many people in the field work under the assumption that PS apotosis is involved in AD. The data in this paper is not consistent with the theory that PS apotosis is impor

Elliott Mufson on Aging and Alzheimer's disease: lessons from the Nun Study.

COMMENT Noteworthy 0 emufson

Benjamin Wolozin on Identification of genes that modify ataxin-1-induced neurodegeneration.

COMMENT This is a gorgeous paper that offers fundamental insights into the mechanism of disease processes. 0 bwolozin

Elliott Mufson on Acetylcholine, aging, and Alzheimer's disease.

COMMENT Useful review. 0 emufson

John Olney on Distribution of the messenger RNA for the extracellularly regulated kinases 1, 2 and 3 in rat brain: effects of excitotoxic hippocampal lesions.

COMMENT The article by Hollister et al provides useful information regarding the potential role of kinase enzymes in NFT formation in that it studies 4 different kinases and shows that only one of them has the proper messenger RNA distribution to make it a logica

Edward Koo on Use of bomb pulse carbon-14 to age senile plaques and neurofibrillary tangles in Alzheimer's disease.

COMMENT Interesting approach. But the dating can be mislead by more turnover of plaques than tangles. 0 edkoo

Hiroshi Mori on Complete genomic screen in late-onset familial Alzheimer's disease.

COMMENT A new locus to explain the great majority of sporadic Alzheimer's disease is examined here. Although it is not yet identified, their trial is shown here in detail which should be respected and be expected. 0 mori

Paul Coleman on Brain volume preserved in healthy elderly through the eleventh decade.

COMMENT Another study for the older folks. 0 Paul_Coleman

Paul Coleman on Presenilins, the endoplasmic reticulum, and neuronal apoptosis in Alzheimer's disease.

COMMENT Would this represent an improvement over other cholinergic agents currently in the pipe;ine for treatment of AD? Is there any expectation that SA4503 would have an effect on the basic mechanism of AD pathology? 0 Paul_Coleman