Hiroshi Mori on Cerebrospinal fluid tau protein as a biochemical marker for Alzheimer's disease: a community based follow up study.

COMMENT Tau is a potent molecular maker for AD diagnosis but is not enough by itself. In any case, we need multiple observations of CSF-tau, such as the present paper. 0 mori

Benjamin Wolozin on Microglial activation and beta -amyloid deposit reduction caused by a nitric oxide-releasing nonsteroidal anti-inflammatory drug in amyloid precursor protein plus presenilin-1 transgenic mice.

COMMENT This paper is an excellent follow up to the paper by Weggen and colleagues showing that a subset of NSAIDs lower Abeta42. This current paper provides the in vivo correlate of what Weggen and colleagues observed, and suggests that despite disappointing cli

Hiroshi Mori on Hemin and related porphyrins inhibit beta-amyloid aggregation.

COMMENT The acculmulation of radical species contribute to AD pathogenesis which include amyloid deposition in AD brain. This article is a good study which showed an aspect of radical formation and its inhibition. 0 mori

Nikolaos K. Robakis on Detection of neuritic plaques in Alzheimer's disease by magnetic resonance microscopy.

COMMENT The ability to follow the early progression of amyloid-positive brain lesions will aid and simplify diagnosis of AD. In addition it will facilitate pharmacological intervention 0 nikos.robakis

Hiroshi Mori on The medial temporal lobe in dementia with Lewy bodies: a comparative study with Alzheimer's disease.

COMMENT DLB is not one disease and the basic study on DLB is rather supposed to contribute to AD, too. The authors' viewpoint is unique and such studies should be more challenged to promote understanding of both disease etiologies. 0 mori

Elliott Mufson on Automated identification and quantitative morphometry of the senile plaques of Alzheimer's disease.

COMMENT Noteworthy 0 emufson

Benjamin Wolozin on A novel peptide prevents death in enriched neuronal cultures.

COMMENT Could be an important new trophic factor. 0 bwolozin

Edward Koo on Tyrosine phosphorylation of the beta-amyloid precursor protein cytoplasmic tail promotes interaction with Shc.

COMMENT Interesting data but more APP binding proteins. What are they all doing? 0 edkoo

Paul Coleman on Biochemical assay for AD7C-NTP in urine as an Alzheimer's disease marker.

COMMENT It is not clear from the abstract how much overlap there may be between AD and controls. Neither is it clear how well this test may distinguish AD from other dementing diseases. 0 Paul_Coleman

Benjamin Wolozin on The intracellular domain of the beta-amyloid precursor protein is stabilized by Fe65 and translocates to the nucleus in a notch-like manner.

COMMENT Recent findings suggest that APP stimulates gene transcription. This study provides important confirmation for that observation. 0 bwolozin

Nikolaos K. Robakis on Modulation of beta-amyloid precursor protein processing by the low density lipoprotein receptor-related protein (LRP). Evidence that LRP contributes to the pathogenesis of Alzheimer's disease.

COMMENT This is a very interesting report. As suggested by the authors, it could lead to the discovery of pharmacological agents that decrease amyloid production by acting on LRP. 0 nikos.robakis

Hiroshi Mori on Human blood-brain barrier receptors for Alzheimer's amyloid-beta 1- 40. Asymmetrical binding, endocytosis, and transcytosis at the apical side of brain microvascular endothelial cell monolayer.

COMMENT This is an important paper showing the biochemical study on Abeta1-40 species in vascular deposition as non-plaque components. 0 mori

Hiroshi Mori on Human recombinant NACP/alpha-synuclein is aggregated and fibrillated in vitro: relevance for Lewy body disease.

COMMENT We need multiple information on synuclein for Lewy body disease etiology. It is informative to know the time required for formation of mature fibrils. 0 mori

Elliott Mufson on No association between apolipoprotein E epsilon 4 allele and rate of decline in Alzheimer's disease.

COMMENT Interesting. 0 emufson

John Olney on High affinity glutamate transporters: regulation of expression and activity.

COMMENT These authors provide a competent review of new findings in the glutamate transporter field, a field which ultimately may provide insights into neurodegenerative diseases. At present they are just beginning to develop the probes necessary to evaluate the