Edward Koo on A gene trap insertion reveals that amyloid precursor protein expression is a very early event in murine embryogenesis.

COMMENT This result is consistent with other studies that APP is upregulated in development, but why? Maybe this is related the proposed signaling function of APP? 0 edkoo

Nikolaos K. Robakis on Overexpression of tau protein inhibits kinesin-dependent trafficking of vesicles, mitochondria, and endoplasmic reticulum: implications for Alzheimer's disease.

COMMENT This paper suggests how tau overexpression which occurs in AD can contribute to neurodegeneration. 0 nikos.robakis

Elliott Mufson on Down syndrome.

COMMENT Good review. 0 emufson

Hiroshi Mori on Congo red inhibits proteoglycan and serum amyloid P binding to amyloid beta fibrils.

COMMENT Congo red is a possible fundamental anti-amyloid deposition drug. Despite the problem that it does not pass the blood-brain barrier, evidence on the effect of congo red on amyloid aggregation, toxicity or binding is expected to accumulate. 0 mori

Hiroshi Mori on Altered cholesterol metabolism in human apolipoprotein E4 knock-in mice.

COMMENT The present mice could be very useful and important for analyzing lipid turnover and amyloid deposition because their apoE is in situ regulated in a physiological fashion. 0 mori

Hiroshi Mori on Metabolism of presenilin 1: influence of presenilin 1 on amyloid precursor protein processing.

COMMENT The most advanced phase of the Tg study is explained here. We should learn from them. 0 mori

Hiroshi Mori on SOD1 rescues cerebral endothelial dysfunction in mice overexpressing amyloid precursor protein.

COMMENT This is the first paper to show the significant function of APP in endothelial cells on AD pathogenesis. 0 mori

Hiroshi Mori on Sialylated human apolipoprotein E (apoEs) is preferentially associated with neuron-enriched cultures from APOE transgenic mice.

COMMENT Further evidence for the presence of neuronal ApoE is provided here. 0 mori

Peter Davies on Apolipoprotein E-containing high density lipoprotein promotes neurite outgrowth and is a ligand for the low density lipoprotein receptor-related protein.

COMMENT A very well done apoE paper 0 peter.davies

Nikolaos K. Robakis on C-terminal maturation fragments of presenilin 1 and 2 control secretion of APP alpha and A beta by human cells and are degraded by proteasome.

COMMENT It seems to me that this paper directly contradicts a recent Nature paper by DeStrooper that proteosome inhibitors had no effect on PS1 (g-secrtase) processing. 0 nikos.robakis

Hiroshi Mori on Protective effects of idebenone and alpha-tocopherol on beta-amyloid-(1-42)-induced learning and memory deficits in rats: implication of oxidative stress in beta-amyloid-induced neurotoxicity in vivo.

COMMENT It is important to see amyloid toxicity on various viewpoints. Oxidative stress is one of the significant issues as seen in this article. 0 mori

Hiroshi Mori on alpha-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with lewy bodies.

COMMENT Lewy bodies and Lewy neurites are shown to be decorated by two antibodies to alpha-synuclein ubiquitin. 0 mori

Hiroshi Mori on Increased vulnerability of hippocampal neurons from presenilin-1 mutant knock-in mice to amyloid beta-peptide toxicity: central roles of superoxide production and caspase activation.

COMMENT The paper show that superoxide is another central molecule for amyloid hypothesis. 0 mori

Hiroshi Mori on Paired helical filament morphology varies with intracellular location in Alzheimer's disease brain.

COMMENT This is basic study we need now because such examination using in vivo brain tissues will produce the detail and accurate mechanism of PHF formation and possibly cell death. 0 mori

Nikolaos K. Robakis on Increased levels of apolipoprotein D in cerebrospinal fluid and hippocampus of Alzheimer's patients.

COMMENT If this data is replicated, it may lead to the development of a diagnostic for AD. 0 nikos.robakis