Hamanaka H, Katoh-Fukui Y, Suzuki K, Kobayashi M, Suzuki R, Motegi Y, Nakahara Y, Takeshita A, Kawai M, Ishiguro K, Yokoyama M, Fujita SC. Altered cholesterol metabolism in human apolipoprotein E4 knock-in mice. Hum Mol Genet. 2000 Feb 12;9(3):353-61. PubMed.
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Osaka City University Medical School
The present mice could be very useful and important for analyzing lipid turnover and amyloid deposition because their apoE is in situ regulated in a physiological fashion.
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