Benjamin Wolozin on Use of lipid-lowering agents, indication bias, and the risk of dementia in community-dwelling elderly people.

COMMENT This paper provides further support for the observation that use of statins is associated with a lower risk of AD. Specifically, this paper reduces the possibility that the negative correlation between statin use and AD is due to the a spurious outcome of

John Hardy on Effect of APOE genotype and promoter polymorphism on risk of Alzheimer's disease.

COMMENT The difficulty we have had proving a role for the polymorphisms in the APOE promoter in AD (and the general consensus seems to be that they have a role), illustrates the difficulty we will have in determining whether genetic variability at other non-codin

Hiroshi Mori on Pathologic amyloid beta-protein cell surface fibril assembly on cultured human cerebrovascular smooth muscle cells.

COMMENT As the authors suggest here, amyloid angiopathy may come from outside the brain, in blood flow. But, it is still questionable whether wild amyloid peptide comes from the same origin as Dutch-type one. 0 mori

Paul Coleman on Phosphorylated tau can promote tubulin assembly.

COMMENT The abstract states 'PKA-phosphorylated tau (2.7 mol phosphates/mol) does not promote tubulin assembly as judged by spectrophotometric and atomic force microscopy measurements, unless trimethylamine N-oxide (TMAO), a natural occurring osmolyte, is in

Hiroshi Mori on Human amyloid precursor-like protein 1--cDNA cloning, ectopic expression in COS-7 cells and identification of soluble forms in the cerebrospinal fluid.

COMMENT Any papers are interesting and important as far as they include the primary sequence of the molecule but this paper for human APLP1 is particularly interesting because its distribution was quite similar to that of APP. 0 mori

Nikolaos K. Robakis on alpha-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with lewy bodies.

COMMENT Elucidation of the abnormal protein aggregations found in Lewy bodies is important as this disease is very much related to AD. 0 nikos.robakis

Hiroshi Mori on Apolipoprotein E polymorphism in patients with Alzheimer's disease, vascular dementia and ischemic cerebrovascular disease.

COMMENT The result says that ApoE epsilon 4 allele influences VD, ICVD as well as AD. This indicates ApoE is a risk factor for amyloid deposition rather than AD specifically. 0 mori

Carl Cotman on Direct conversion of an oligopeptide from a beta-sheet to an alpha-helix: a model for amyloid formation.

COMMENT Reversibility is northy. 0 cwcotman

Hiroshi Mori on Effect of apolipoprotein E allele epsilon4 on the initial phase of amyloid beta-protein accumulation in the human brain.

COMMENT ApoE4 is suggested to have a similar effect on Abeta42 as the early onset genes like PS1, PS2 or APP. 0 mori

Benjamin Wolozin on Protein kinase C regulation of intracellular and cell surface amyloid precursor protein (APP) cleavage in CHO695 cells.

COMMENT Important new information about the mechanism of APP processing. 0 bwolozin

Carl Cotman on Linkage of frontotemporal dementia to chromosome 17: clinical and neuropathological characterization of phenotype.

COMMENT New lead on subtype risk factors and their genetic basis. 0 cwcotman

Hiroshi Mori on Presenilins interact with armadillo proteins including neural-specific plakophilin-related protein and beta-catenin.

COMMENT It is established that NPRAP is the presenilin-binding protein which may regulate amyloid tunover. 0 mori

Hiroshi Mori on Immunoreactivity of presenilin-1 and tau in Alzheimer's disease brain.

COMMENT This paper is virtually negative data but it is useful to see that PS1 is not associated with neuropathological changes. 0 mori

Nikolaos K. Robakis on A familial case of Alzheimer's disease without tau pathology may be linked with chromosome 3 markers.

COMMENT This is an interesting report as it may lead to the identification of another gene causing the Plaque-only form of AD. 0 nikos.robakis

Paul Coleman on Colocalization of BAX and BCL-2 in small intestine and kidney biopsies with different degrees of DNA fragmentation.

COMMENT This is not brain cells, but appears to have some interesting things to say about expression of BAX and BCL-2 in relation to DNA fragmentation, chromatin condensation and cellular shrinkage. 0 Paul_Coleman