Hiroshi Mori on Corticobasal ganglionic degeneration and progressive supranuclear palsy presenting with cognitive decline.

COMMENT Growing evidence has shown the pathological significance of tau, synuclein and ubiquitin in AD, but these molecules have not been identified as specific to AD. Related disorders must be examined more for these molecules to understand their etiology. 0 mor

Hiroshi Mori on Generation of anti-apoptotic presenilin-2 polypeptides by alternative transcription, proteolysis, and caspase-3 cleavage.

COMMENT Apoptosis is currently a hot topic worth examining for its possible role in AD. More evidence on Caspase-3 must be investigated. 0 mori

Paul Coleman on Prevalence and incidence of clinically diagnosed memory impairments in a geographically defined general population in Sweden. The Piteå Dementia Project.

COMMENT The statistics presented here seem to be at variance with recently published data from other institutions. 0 Paul_Coleman

Elliott Mufson on Interfamilial and intrafamilial phenotypic heterogeneity in familial Alzheimer's disease.

COMMENT Interesting 0 emufson

Alison Goate on The APOE-epsilon4 allele and the risk of Alzheimer disease among African Americans, whites, and Hispanics.

COMMENT Interesting paper highlighting differences in relative risk for ad associated with apoe4 genotype in different ethnic populations. Suggests that Hispanic or African a American populations might be a good place to start looking for other genetic risk facto

Paul Coleman on Relating anatomy to function in Alzheimer's disease: neuropsychological profiles predict regional neuropathology 5 years later.

COMMENT This represents a tremendous amount of careful work. The neuropathological data obtained when the patients died 5 years after testing showed that cored senile plaques were 'systematically related' to psychometric factors. This represents on of t

Benjamin Wolozin on Expression of apoptosis related proteins in brains of patients with Alzheimer's disease.

COMMENT There has been a longstanding debate about the role of apoptosis in AD. This paper provides some new details on this debate by identifying which pro-apoptotic proteins are elevated in AD. The selective elevation of particular proteins provides important c

Hiroshi Mori on Abnormal localization of iron regulatory protein in Alzheimer's disease.

COMMENT IRP-2 but not IRP-1 might be directly linked to impaired iron homeostasis in Alzheimer's disease. Such a specific role may suggest a causal relationship between iron disturbance and AD pathology. 0 mori

Benjamin Wolozin on Angiotensin-converting enzyme degrades Alzheimer amyloid beta-peptide (A beta ); retards A beta aggregation, deposition, fibril formation; and inhibits cytotoxicity.

COMMENT This is an important finding. Increasing evidence suggests that mechanisms for degrading Abeta impact on the disease process. Whether such enzymes can be used to reduce Abeta levels remains to be determined. 0 bwolozin

Hiroshi Mori on Presenilin-1 mutations downregulate the signalling pathway of the unfolded-protein response.

COMMENT This is a nice cell biological study on AD. Perturbation at ER documented here is deeply related with all types of AD. Further investigation is welcome. 0 mori

Paul Coleman on Hyperactivation of mitogen-activated protein kinase increases phospho-tau immunoreactivity within human neuroblastoma: additive and synergistic influence of alteration of additional kinase activities.

COMMENT Another important paper on potential interactions among kinases in tau phosphorylation. 0 Paul_Coleman

Hiroshi Mori on Presenilin 1 intronic polymorphism is not associated with Alzheimer type neuropathological changes or sporadic Alzheimer's disease.

COMMENT This study also shows the absence of relationship between PS-1 polymorphophism and non-familial sporadic AD patients. Negative results are as interesting as positive ones. 0 mori

Andre Delacourte on Cytoarchitectonic alterations in the supramarginal gyrus of late onset Alzheimer's disease.

COMMENT One of the first papers showing clearly, with an excellent approach, what was expected: there is a relationship between the presence of tangles and neuronal loss. Also, cognitive impairment is better correlated with the density of tangles than with the ne

Hiroshi Mori on Intracellular accumulation of detergent-soluble amyloidogenic A beta fragment of Alzheimer's disease precursor protein in the hippocampus of aged transgenic mice.

COMMENT Experimental animals enable us to study a mechanism for plaque formation from the soluble amyloid to insoluble amyloid. Little information [has been available for] distinguishing [the metabolism of] these two species. This study is one of the important wo

Hiroshi Mori on Expression of ced-3 and ced-9 homologs in Alzheimer's disease cerebral cortex.

COMMENT If apoptosis is positively involved in AD pathogenesis, their expression of related genes should be alterated. This is one of such examinations and should be referred. 0 mori