Hiroshi Mori on Alzheimer disease: quantitative H-1 MR spectroscopic imaging of frontoparietal brain.

COMMENT Imaging analyses such as MRI can be powerful method for diagnosis and should become more useful when used with other biochemical analyses in the future. 0 mori

Elliott Mufson on Alzheimer's disease in twins.

COMMENT Noteworthy. 0 emufson

Benjamin Wolozin on Anti-amyloidogenic activity of tetracyclines: studies in vitro.

COMMENT Potential therapeutic approach in AD. Comes on the heals of Bush’s work showing that another antibiotic reduces plaque formation (through a chelation mechanism). 0 bwolozin

Carl Cotman on Brain blood flow in the dementias: SPECT with histopathologic correlation in 54 patients.

COMMENT Important 0 cwcotman

Hiroshi Mori on Modulation of nitric oxide production in human macrophages by apolipoprotein-E and amyloid-beta peptide.

COMMENT Little is known about accumulation after APOE spcies' cellular reactions. Such information is needed when we speculate APOE function on neuropathological cascade in Alzheimer's disease brain. 0 mori

Paul Coleman on A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain.

COMMENT The abstract states: 'Thus the targeting of gamma-secretase for the treatment of Alzheimer's disease may risk toxicity caused by reduced Notch signalling.' A potentially important cautionary note. 0 Paul_Coleman

Hiroshi Mori on Proteolytic release and nuclear translocation of Notch-1 are induced by presenilin-1 and impaired by pathogenic presenilin-1 mutations.

COMMENT This is clearl [evidence] for PS1's [role in the] function on cleavage and recruitment of Notch-1. Undoubtedly, this is one of the most important papers in this field. 0 mori

Paul Coleman on Cytoarchitectonic alterations in the supramarginal gyrus of late onset Alzheimer's disease.

COMMENT It is not clear whether the authors used appropriate unbiased stereological methods to estimate numbers of neurons, NFT and plaques. 0 Paul_Coleman

Paul Coleman on The biochemical pathway of neurofibrillary degeneration in aging and Alzheimer's disease.

COMMENT This paper describes a progression of NFT pathology along a stereotyped, hierarchical and morphologically sequential pathway. The progression was categorized into 10 stages according to the brain regions affected, starting with transentorhinal cortex and

Hiroshi Mori on Apolipoprotein E polymorphism in elderly east Africans.

COMMENT Racial comparison of ApoE alleles will provide some information of molecular mechanism of the disease etiology. 0 mori

Paul Coleman on Neuropathologic diagnosis of Alzheimer disease: consensus between practicing neuropathologists?

COMMENT These data are very pertinent to the recently published issue of Neurobiology of Aging (vol. 18, 1997) "Consensus Recommendations for the Postmortem Diagnosis of Alzheimer's Disease". The final consensus recommendation of the meeting that p

Edward Koo on Augmented senile plaque load in aged female beta-amyloid precursor protein-transgenic mice.

COMMENT Intersting report of sex difference in amyloid pathology in transgeni mice. Relevance to estrogen effect in AD? 0 edkoo

Edward Koo on Clearance of Alzheimer's amyloid-ss(1-40) peptide from brain by LDL receptor-related protein-1 at the blood-brain barrier.

COMMENT In vivo evidence that abeta is physiologically cleared in brain. 0 edkoo

Nikolaos K. Robakis on Neuronal overexpression of mutant amyloid precursor protein results in prominent deposition of cerebrovascular amyloid.

COMMENT An interesting paper because it sheds light on the mechanism of cerebrovascular amyloidosis 0 nikos.robakis

John Olney on Postnatal retinal ganglion cells in vitro: protection against reactive oxygen species (ROS)-induced axonal degeneration by cocultured astrocytes.

COMMENT This is an interesting paper in which cerebrocortical astrocytes are grown together with retinal ganglion cells in culture and it is shown that the presence of the astrocytes prevents reactive oxygen species from causing axonal degeneration. It is not cle