Hiroshi Mori on Paired helical filaments in corticobasal degeneration: the fine fibrillary structure with NanoVan.

COMMENT NanoVan, a novel staining reagent, maybe attractive to distinguish different PHF structure in various disease. 0 mori

Benjamin Wolozin on On the turnover of brain cholesterol in patients with Alzheimer's disease. Abnormal induction of the cholesterol-catabolic enzyme CYP46 in glial cells.

COMMENT Increasing evidence suggests that elements of the cholesterol pathway regulate Abeta production. This increases the importance of understanding cholesterol metabolism and trafficking in the brain. The discovery of disease related changes in cholesterol me

Hiroshi Mori on Decreased melatonin levels in postmortem cerebrospinal fluid in relation to aging, Alzheimer's disease, and apolipoprotein E-epsilon4/4 genotype.

COMMENT It proves clearly that melatonin is a neurotransmitter which disturbs in AD brain. 0 mori

John Hardy on Reduced effectiveness of Abeta1-42 immunization in APP transgenic mice with significant amyloid deposition.

COMMENT Clearly of practical relevance to therapy. 0 J.Hardy

Benjamin Wolozin on Evidence for genetic linkage of Alzheimer's disease to chromosome 10q.

COMMENT Genes causing AD are clearly important. 0 bwolozin

Hiroshi Mori on Heparin oligosaccharides that pass the blood-brain barrier inhibit beta-amyloid precursor protein secretion and heparin binding to beta-amyloid peptide.

COMMENT This study on heparin is expected to further our understanding of the interaction with amyloid and has possible implications for a clinical therapy. 0 mori

Hiroshi Mori on The proteolytic fragments of the Alzheimer's disease-associated presenilin-1 form heterodimers and occur as a 100-150-kDa molecular mass complex.

COMMENT It is interesting to see PS-1 in brain tissue. This shows the complex formation of PS1 by ultracentrifugation. The data may contribute to the study of PS1 binding proteins. 0 mori

Benjamin Wolozin on A beta peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer's disease.

COMMENT Important animal model of AD. 0 bwolozin

John Olney on Peroxynitrite modulates tyrosine phosphorylation and phosphoinositide signalling in human neuroblastoma SH-SY5Y cells: attenuated effects in human 1321N1 astrocytoma cells.

COMMENT Li et al describe the effects of peroxynitrite (free radical generated in nitric oxide pathways) on second messenger systems in cultured human tumor cells. Although the authors point to the possible relevance of their findings to AD, no direct link to AD

Elliott Mufson on Atrophy of the hippocampus, parietal cortex, and insula in Alzheimer's disease: a volumetric magnetic resonance imaging study.

COMMENT Interesting study. 0 emufson

Gerry Fischbach on Cholinergic activation of phosphoinositide signaling is impaired in Alzheimer's disease brain.

COMMENT Not clear what the PI signalling system does- the regional differences may be interesting. Which regions?- This is important. Are they the areas most affected by the disease? 0 gf224

Edward Koo on Interaction with telencephalin and the amyloid precursor protein predicts a ring structure for presenilins.

COMMENT Another function for ps, also related to protein degradation but not like app or notch clevage. 0 edkoo

Paul Coleman on The order of exposure of tau to signal transduction kinases alters the generation of "AD-like" phosphoepitopes.

COMMENT The concept of sequential influence of kinases on successive phosphorylations of tau is an important one and this paper presents additional experimental clarification of the role of several kinases. 0 Paul_Coleman

Hiroshi Mori on In vitro peroxidase oxidation induces stable dimers of beta-amyloid (1-42) through dityrosine bridge formation.

COMMENT It is worth while to study oxidation function on amyloid toxicity and polymerization. 0 mori

Paul Coleman on Comparison of beta-protein/A4 deposits and Alz-50-stained cytoskeletal changes in the hypothalamus and adjoining areas of Alzheimer's disease patients: amorphic plaques and cytoskeletal changes occur independently.

COMMENT Although the data presented here are consistent with other studies, the interpretation of these data requires making assumptions about the life history of the A beta deposits and Alz 50 changes revealed by the methods used. 0 Paul_Coleman