11572 RESULTS
COMMENT This is important for its demonstration that 'The combined total of unaffected pyramidal neurons, iNFTs and eNFTs was.. relatively constant' suggesting that ghost tangles are not eventually lost. 0 Paul_Coleman
COMMENT I don't think this study argues for distinct proteolytic activities. One cannot saturate g-secretase activity by over-expressing APP. 0 edkoo
COMMENT This is an interesting finding as it suggests a possible link between ischemia and tau phosphorylation. 0 nikos.robakis
COMMENT This paper shows the involvment of the extracellular matrix (fibronectin, a receptor for the alpha 5 beta 1 integrin) in amyloid-derived toxic reaction. 0 mori
COMMENT Kuhn et al claim that clinical studies have shown that selegiline, an MAO-B inhibitor, is therapeutically beneficial in Parkinson's and Alzheimer's diseases. In the present paper they report that selegiline influences cytokine biosynthesis and t
COMMENT Since their study is on the linking between Apo E receptor and AD, they examine more risk factors to explain other sporadic cases. 0 mori
COMMENT This paper helps to resolve the very important issue of the involvement of PS mutations in sporadic AD. 0 nikos.robakis
COMMENT Laminin's effect on Abeta 42 may be a clue for the possible treatment in future. 0 mori
COMMENT 'In conclusion, multivariate pattern recognition shows that AD is composed of independent neuropathological subtypes and NFT in area 23 do not account for most neuron losses.' Another study showing that NFT are not obligatory for the excess neur
COMMENT Upregulation of Bak, Bad, Bcl-2 and Bcl-x are observed in AD brains but it is still not known what the primary event is that is responsible for these changes. 0 mori
COMMENT The recent advance of Mass spectrometry is great. It is useful to analyze protein chemistry of normal and abnormal peptide and its derivative in human material even in the presence of sait. 0 mori
COMMENT Interesting 0 emufson
COMMENT The inflammatory hypothesis is an attractive one for the treatment of Alzheimer's disease. Specific inflammatory to AD pathogenesis must be clinically and experimentally studied from multiple viewpoints. 0 mori
COMMENT Cofactors to promote amyloid fibrils are expected to have some important role in pathogenesis of Alzheimer's disease. HEPARIN is one of these factors and attractive from the view point of PHF formation. 0 mori
COMMENT If replicated, this is an interesting finding as it may indicate a way to inhibit Ab production. 0 nikos.robakis
