Carl Cotman on The deterioration of semantic networks in patients with Alzheimer's disease: a cross-sectional study.

COMMENT Interesting 0 cwcotman

Paul Coleman on Aluminum but not iron treatment induces pro-oxidant events in the rat brain.

COMMENT These data appear to be at some variance with other data in the literature. 0 Paul_Coleman

Nikolaos K. Robakis on Soluble amyloid beta peptide concentration as a predictor of synaptic change in Alzheimer's disease.

COMMENT This report deserves further attention as it suggests for the first time that soluble Ab 1-40 may correlate closer to AD than either Ab1-42 or NFTs. 0 nikos.robakis

Hiroshi Mori on Presenilin 1 mutations linked to familial Alzheimer's disease increase the intracellular levels of amyloid beta-protein 1-42 and its N-terminally truncated variant(s) which are generated at distinct sites.

COMMENT The effect of PS1 mutation on amyloid is significant. Little concern was paid to amyloid speceis in the insoluble fraction including intracellular beside the soluble fraction. This paper gives us further knowledge to understand the PS1 function in cells.

Hiroshi Mori on Inhibiting the formation of classical C3-convertase on the Alzheimer's beta-amyloid peptide.

COMMENT It is interesting to see the relationship between immuno response and amyloid plaque fomation. Evidence is not enough to discuss the etiology but this paper is one of studies on this route. 0 mori

Hiroshi Mori on Interaction of tau with the neural membrane cortex is regulated by phosphorylation at sites that are modified in paired helical filaments.

COMMENT This is a new insight. It remains to be discovered whether further component(s) exists between the end of microtubule and PM. 0 mori

Nikolaos K. Robakis on Early amyloid deposition in the medial temporal lobe of young Down syndrome patients: a regional quantitative analysis.

COMMENT This is an interesting paper as it indicates the progression of Ab deposition which seems to start in the parahippocampal gyrus. Interestingly,the first neuritic plaques do not appear in the region that Ab is first deposited suggesting that additional (un

Paul Coleman on Variation in hippocampal neuron number with age and brain volume.

COMMENT The findings of this study show that, in neurologically normal individuals, brain size is a major determinant of the number of CA1 neurons. It appears this study was well done using modern stereological methods. 0 Paul_Coleman

Hiroshi Mori on Corticobasal ganglionic degeneration and progressive supranuclear palsy presenting with cognitive decline.

COMMENT Growing evidence has shown the pathological significance of tau, synuclein and ubiquitin in AD, but these molecules have not been identified as specific to AD. Related disorders must be examined more for these molecules to understand their etiology. 0 mor

Hiroshi Mori on Generation of anti-apoptotic presenilin-2 polypeptides by alternative transcription, proteolysis, and caspase-3 cleavage.

COMMENT Apoptosis is currently a hot topic worth examining for its possible role in AD. More evidence on Caspase-3 must be investigated. 0 mori

Paul Coleman on Prevalence and incidence of clinically diagnosed memory impairments in a geographically defined general population in Sweden. The Piteå Dementia Project.

COMMENT The statistics presented here seem to be at variance with recently published data from other institutions. 0 Paul_Coleman

Elliott Mufson on Interfamilial and intrafamilial phenotypic heterogeneity in familial Alzheimer's disease.

COMMENT Interesting 0 emufson

Alison Goate on The APOE-epsilon4 allele and the risk of Alzheimer disease among African Americans, whites, and Hispanics.

COMMENT Interesting paper highlighting differences in relative risk for ad associated with apoe4 genotype in different ethnic populations. Suggests that Hispanic or African a American populations might be a good place to start looking for other genetic risk facto

Paul Coleman on Relating anatomy to function in Alzheimer's disease: neuropsychological profiles predict regional neuropathology 5 years later.

COMMENT This represents a tremendous amount of careful work. The neuropathological data obtained when the patients died 5 years after testing showed that cored senile plaques were 'systematically related' to psychometric factors. This represents on of t

Benjamin Wolozin on Expression of apoptosis related proteins in brains of patients with Alzheimer's disease.

COMMENT There has been a longstanding debate about the role of apoptosis in AD. This paper provides some new details on this debate by identifying which pro-apoptotic proteins are elevated in AD. The selective elevation of particular proteins provides important c