Kitamura Y, Shimohama S, Kamoshima W, Ota T, Matsuoka Y, Nomura Y, Smith MA, Perry G, Whitehouse PJ, Taniguchi T. Alteration of proteins regulating apoptosis, Bcl-2, Bcl-x, Bax, Bak, Bad, ICH-1 and CPP32, in Alzheimer's disease. Brain Res. 1998 Jan 12;780(2):260-9. PubMed.
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Osaka City University Medical School
Upregulation of Bak, Bad, Bcl-2 and Bcl-x are observed in AD brains but it is still not known what the primary event is that is responsible for these changes.
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