Lucius R, Sievers J.
Postnatal retinal ganglion cells in vitro: protection against reactive oxygen species (ROS)-induced axonal degeneration by cocultured astrocytes.
Brain Res. 1996 Dec 16;743(1-2):56-62.
PubMed.
This is an interesting paper in which cerebrocortical astrocytes are grown together with retinal ganglion cells in culture and it is shown that the presence of the astrocytes prevents reactive oxygen species from causing axonal degeneration. It is not clear from the abstract whether the axonal degeneration occurs independent of an effect on ganglion cells. Therefore the study is difficult to interpret. The authors speculate on the mechanism but do not present any evidence to document a mechanism. In addition to the mechanisms mentioned, it is possible that the high capacity of astrocytes to take up glutamate and prevent it from interacting with receptors warrants consideration
Comments
This is an interesting paper in which cerebrocortical astrocytes are grown together with retinal ganglion cells in culture and it is shown that the presence of the astrocytes prevents reactive oxygen species from causing axonal degeneration. It is not clear from the abstract whether the axonal degeneration occurs independent of an effect on ganglion cells. Therefore the study is difficult to interpret. The authors speculate on the mechanism but do not present any evidence to document a mechanism. In addition to the mechanisms mentioned, it is possible that the high capacity of astrocytes to take up glutamate and prevent it from interacting with receptors warrants consideration
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