11633 RESULTS
COMMENT The impressive paper by Tuszynski and colleagues represents a very promising outlook into possible future therapy of AD: They isolate patients' own fibroblasts from a skin sample, expand the cells in cell cultures, and transduce them to overexpress N
COMMENT Michio Hashimoto has shown significant improvement in cognition in rats given β-amyloid infusions into the cerebral ventricles, when the brain was protected with orally administered omega-3 fatty acids (DHA) (Hashimoto et al.,2005.) In addition to better
COMMENT Recently, Cleary et al. reported that conditioned medium from a 7PA2 cell line that stably expresses mutant APP disrupts learning behavior when microinjected intracerebroventricularly into rats. More importantly, the authors demonstrated that oligomers (t
COMMENT The report by Tuszynski et al. is a fascinating study on many levels. First, the ability to deliver ex vivo nerve growth factor (NGF) via autologous fibroblasts genetically modified to express NGF for greater than 18 months into the nucleus basalis of Mey
COMMENT This is a very exciting study. It should be discussed together with the recent paper from the Sisodia group (Lazarov et al., 2005). Is the effect seen in the Lazarov et al. study due to exercise alone? Alternatively, do exercise and environment enrichment
COMMENT This paper is in agreement with results presented by Carlos Dotti showing that reducing Aβ production via the cholesterol pathway could be dangerous. 0 andre.delacourte The conflicting role of brain cholesterol in Alzheimer's disease: lessons from th
COMMENT The data presented here are consistent with many previous studies establishing the central role of synapses in congnitive impairment in AD. It is unfortunate that the limit of 7 proteins examined here did not allow the authors to distinguish differential
COMMENT This study represents an important advance in establishing solid in vivo proof-of-concept for eventual human therapeutics directed toward soluble, neurotoxic Aβ oligomers, also known as ADDLs. This study confirms results from other studies that passive im
COMMENT Dr. Norman Relkin and colleagues reported about the use of intravenous immunoglobulin (IVIG) in patients with AD. Unfortunately, the amount of anti-Aβ antibodies in the IVIG is difficult to measure and it should be very low. At the same time it is importa
COMMENT Conner et al. (2005) show in this elegant paper that the basal forebrain cholinergic system plays an essential role in cortical plasticity and functional recovery following brain injury. Thus, even partial cholinergic hypofunction may cause a disruption o
COMMENT I think the most interesting aspect of the recent Connor et al. article is that it builds on their earlier work, which showed that nucleus basalis cholinergic neurons were necessary for the normal changes in motor cortex representation that happen during
COMMENT Petersen and colleagues have recently presented the results of a superb study in which they showed convincing evidence that in subjects who met the clinical criteria for amnestic mild cognitive impairment (MCI), donepezil, a cholinesterase inhibitor, or v
COMMENT These are significant findings, suggesting a role for truncated alphaSyn in the pathogenesis of alphaSyn aggregation and disease, whereby incomplete degradation of alphaSyn may produce highly amyloidogenic fragments that contribute to the aggregation of f
COMMENT Please access article in Nature news July 2004 re "Lithium may fend off Alzheimer's disease". It is available to Premium Plus subscribers to news@nature.com, available to institutions or at a rate of 15.99 per month. Both my deceased brothe
COMMENT An interesting observation. Another explanation could be that neurons that suffer from a degenerative disorder tend to overproduce Aβ to counteract the oxidative stress. 0 andre.delacourte
