11633 RESULTS
COMMENT The possible effect of this study on the use of cholinesterase inhibitors is a complex issue because the widespread use of donepezil and other cholinesterase inhibitors is for established AD, not MCI, and the study doesn't speak to that. I believe us
COMMENT Leon Thal and Ron Petersen presented data at the AAN meeting on 4/13/05 that was published today in the NEJM. It compared the effects of donepezil, vitamin E, and placebo in patients who met clinical criteria for amnestic mild cognitive impairment (MCI).
COMMENT The work by Norman Relkin is an intriguing approach to passive immunotherapy. IVIG has been safely administered to thousands of patients and has a good safety record. It is readily available and FDA-approved for other indications. The study presented is o
COMMENT Dr. Norman Relkin and colleagues presented data at this year’s American Academy of Neurology meeting on the use of intravenous immunoglobulin (IVIG) in patients with Alzheimer disease. IVIG is utilized to treat several neurological disorders that have an
COMMENT Prana's decision to cancel the phase II/III "PLACQUE" clinical trial of PBT1 is, of course, disappointing. PBT1 (clioquinol or "CQ") is an old drug that required redevelopment of its synthetic route to meet today's GMP standa
COMMENT I think that the general approach is a real tour de force, and could usher in a potential wave of corrective gene therapy, particularly for developmental disorders that can be identified in utero, or for disorders that affect the immune system, where immu
COMMENT Multiple system atrophy (MSA) is a devastating neurodegenerative disorder that presents with a variety of symptoms that can be categorized broadly into two phenotypic groups, either parkinsonism or cerebellar ataxia. These phenotypes reflect the predomina
COMMENT Why are prion proteins able to propagate in one species and not another? What happens during the rare events when strains of prion proteins are able to breach the species barrier? These critical questions, elegantly addressed by the recent papers from Sur
COMMENT Having read this paper, Larry Goldstein's paper, his group's reply, and comments
COMMENT Liver X Receptors and Neurodegenerative Diseases A growing body of literature suggests that cholesterol plays a central role in multiple neurodegenerative diseases. This paper provides further evidence for the importance of cholesterol following the origi
COMMENT Roy Walford, a scientist at the University of California, was willing to go to extreme lengths to extend his life. After finding that rodents fed an incredibly skimpy diet lived long lives, Walford put himself on equally bare rations, consuming a mere 1,6
COMMENT Caloric restriction has been shown to extend longevity and delay the onset of many age-related diseases in almost every species tested (Lane et al., 2002; McCay et al., 1935; Weindruch and Walford, 1988). Based on this, it would not be surprising, at leas
COMMENT Mitochondria: Another Dimension in Protein Misfolding A growing body of evidence indicates that mitochondrial abnormalities play an important role in the development of neurodegenerative diseases. In addition, mitochondrial abnormalities appear to be a ce
COMMENT This review addresses an extremely important issue in the field of dementia research, that is, the fundamental contribution of vascular factors in the development of Alzheimer disease (AD), vascular dementia (VaD) and a mixture of the two, or so-called “m
COMMENT This is a very significant paper. It represents an important new chapter in AD imaging by developing and testing novel non-radioactive ligands for Aβ plaques. The authors show they can visualize the plaque burden in experimental animal models of AD-like A
