11633 RESULTS
COMMENT The results reported in this paper demonstrate that p66Shc is involved in the neuronal death induced in vitro by Aβ. Further studies on this topic could be of help to address the relevance of oxidative stress induced by Aβ in vivo, and its role in AD neur
COMMENT An interesting paper, suggesting involvement of mitochondria in fronto-temporal dementia. 0 nikos.robakis
COMMENT This paper opens new avenues for noninvasively monitoring Alzheimer disease (AD)-like Abeta deposits in animal models using non-radioactive probes that could facilitate diagnosis of AD and clinical trials of potential AD drugs aimed at reducing Abete plaq
COMMENT The study extends insights into the consequences of tau pathology that involve a mitochondrial and oxidative stress. 0 trojanow
COMMENT That's interesting! 0 neurojun
COMMENT This is really a breakthrough for Alzheimer's diesease research. I think this technique can be used for a variety of in vivo studies, e.g. to see how immune cells interact with target cells. 0 jux1
COMMENT Nimmerjahn et al. have used the two-photon imaging technique to demonstrate the dynamic action of microglial cells in vivo. They were provided with a green fluorescent microglia cell line by S. Jung and D.R. Littman. In their elegantly illustrated paper,
COMMENT 1. It is scientifically and nutritionally ridiculous to give vitamin E without simultaneously replacing peroxidized long-chain omega-3 and omega-6 polyunsaturated essential fatty acids in critical brain synapses (and in mitochondrial membranes, to prevent
COMMENT Maybe Tarvacin could be helpful in targeting through vascular? Just a thought and I don't know if this will be helpful or not, but I had to try. mljacob 0
COMMENT The real nail in the coffin for any drug whatsoever for the blind empirical treatment of Alzheimer's disease is knowing what causes the disease, which is (quite simply) vacuum steam-deodorized, Vitamin E-depleted polyunsaturated vegetable oils (soya
COMMENT This is an elegant paper demonstrating downstream events that tie Abeta toxicity and oxidative stress. 0 lhtsai
COMMENT This paper by Mark Cookson’s group is very exciting: While it starts answering some of the numerous issues regarding PINK1 function, at the same time it poses new, intriguing questions. There are at least two important messages in this paper. First, the a
COMMENT The Alzheimer's Disease Cooperative Study Group MCI trial results regarding donepezil are very encouraging and should be used to stimulate a primary prevention trial. The New England Journal report did not offer a molecular mechanism to explain donep
COMMENT comment regarding the Petersen et al. MCI trial results is that better drugs than those currently
COMMENT RNAi Therapy Works in Animal Models Scott Harper et al. recently demonstrated that RNA interference (RNAi) can treat Huntington disease in an animal model (Harper et al., 2005). This work, together with a previous published experiment from the same group
