11633 RESULTS
COMMENT This interesting report by Zhou et al. suggests that intramembranous cleavage of APP by γ-secretase is negatively regulated by a cell surface type I membrane protein, termed CD147/basigin/EMMPRIN, which belongs to the immunoglobulin superfamily. The autho
COMMENT This week marks publication of a provocative study by Sparks et al. (Sparks et al., 2005). This study suggests that treatment with atorvastatin reduces the progression of Alzheimer disease (AD) in subjects with mild to moderate forms of the disease. The r
COMMENT The recent manuscript by Zhou et al. clearly shows that CD147 co-purifies with the γ-secretase complex. However, the claim that it is a novel regulatory subunit of the complex is likely to be debated. CD147 is a type 1 membrane protein that is in the IgG
COMMENT The analysis of a subset of patients for whom CSF samples were available before and after production of anti-Aβ antibodies suggests that successful immunization with Aβ may retard further neurodegeneration. Although the number of patients studied is very
COMMENT In response to the paper by Sparks et al.: Recently, several studies reported an absence of noticeable effects on cognition in treated AD patients. All of these studies had as a common denominator the use of low or moderate statin dosages, and for most of
COMMENT While the data on mortality in these investigative studies with galantamine in mild cognitive impairment (MCI) obviously give rise to the usual extra caution for treating this older group of patients, it is necessary to put the data in the right context.
COMMENT Of further interest is the finding by Kim et al. that DJ-1 is a regulator of PTEN. emaryreid 0 DJ-1, a novel regulator of the tumor suppressor PTEN.
COMMENT Indeed, since some time I have been thinking about the need to search for protofibril stabilizers, i.e., substances, possibly but not necessarily amphipathic, able to interact with early oligomers of misfolded proteins or peptides by masking their exposed
COMMENT The findings of Hochedlinger et al. provide an important advance in our understanding of the contribution of the POU-domain transcription factor, Oct-4, to stem cells and their differentiation in mammals. Their data strongly suggest that ectopic expressio
COMMENT Might we expect that the anti-inflammatory PPAR-γ agonists which upregulate PTEN may be especially beneficial for those with PINK1-PTEN-induced putative kinase 1 mutations? emaryreid 0 PPAR-gamma modulates allergic inflammation through up-regulation of PT
COMMENT In this interesting paper, Kukar and colleagues report that many NSAIDs and their derivatives selectively raise Aβ42 and lower Aβ38 secretion. These results are surprising, given the group’s original finding that another subset of NSAIDs do just the oppos
COMMENT Aging, including age-related disease, is currently postulated to be the outcome of a large number of disparate influences. Based on the analysis of familial models of late-onset diseases such as Alzheimer’s, a number of biochemical processes, such as prot
COMMENT generation in cells. Regardless of these comments, the current paper advances the field by demonstrating
COMMENT The work by Schriner and colleagues is an important advance in understanding the free radical theory of aging and its implications for healthy aging and longevity. These investigators created transgenic mice that overexpress human catalase localized to pe
COMMENT The findings of Schriner et al. provide an important advance in understanding the contributions of metabolism of reactive oxygen species to aging and lifespan in mammals. Their data strongly suggest that production of hydrogen peroxide in mitochondria is
