Mary Reid on Neurotoxic Homocysteine Metabolite Boosts Intracellular Aβ

COMMENT Zou et al. (1) report that γ-secretase is involved in the processing of megalin. In view of the fact that megalin binds cubilin, the receptor for B12-intrinsic factor complex, and mediates uptake of the vitamin B12-transcobalamin complex (2), what are the

Tommaso Russo on Up-regulation of inhibitors of protein phosphatase-2A in Alzheimer's disease.

COMMENT The observation of the relocalization of I2PPA2/SET/TAF-1 from the nucleus to the cytoplasm in AD neurons is of particular interest because of the possible role of this phosphatase inhibitor in the hyperphosphorylation of tau. Furthermore, we have recentl

J. Lucy Boyd on Anchors Aweigh—Making Amyloid out of Prions

COMMENT I believe these are potentially very significant findings. FNightingale512 0

Larry Sparks on Atorvastatin, Vaccine Trial Data Published

COMMENT I must start by saying that it is quite gratifying that there has been such interest in our clinical trial (AD Cholesterol-Lowering Treatment—ADCLT trial; the Lipitor trial) (1). As the very first AD treatment trial testing a statin medication for clinica

Sigfrido Scarpa on Neurotoxic Homocysteine Metabolite Boosts Intracellular Aβ

COMMENT Aβ species, my comment is that HA administration, by changing the methylation status of membrane

Andrew McCaddon on Neurotoxic Homocysteine Metabolite Boosts Intracellular Aβ

COMMENT Homocysteine, oxidative stress, and AD: An even more vicious cycle! Commenting on Hasegawa et al.,

John Nambu on A New Program for Cell Death: Necroptosis Premiering in a Neuron Near You

COMMENT The paper by Degterev et al. is a tour de force characterization of necroptosis, a non-apoptotic form of programmed cell death that involves necrosis and autophagy. Existence of this caspase-independent pathway was hypothesized from observations that seve

wang jiacai on Classic toxin-induced animal models of Parkinson's disease: 6-OHDA and MPTP.

COMMENT very good 0 gdnfgdnf

Mark Cookson on Search and Rescue in Parkin Fly Mutants—DA Neurons Are Lost, but Saved by GST

COMMENT The main novel observation in this very exciting paper from Whitworth and colleagues is that there is a subtle loss of catecholaminergic neurons in parkin knockout flies. Mouse models have generally not found any loss of dopaminergic neurons, although a r

Li-Huei Tsai on Neurotransmitter Acetylcholine Negatively Regulates Neuromuscular Synapse Formation by a Cdk5-Dependent Mechanism

COMMENT Benjamin A. Samuels and Li-Huei Tsai Postsynaptic clusters of acetylcholine receptors (AChR) form at the developing neuromuscular junction (NMJ) prior to apposition by the presynaptic nerve terminal. Subsequently, clusters that are innervated by the nerve

Akihiko Nunomura on Neurotoxic Homocysteine Metabolite Boosts Intracellular Aβ

COMMENT Homocysteine and AD: More Than Meets the Eye Hyoung-gon Lee, Mark A. Smith, Barney Dwyer, Aki Nunomura, George Perry, Xiongwei Zhu Increased levels of plasma homocysteine (HC), a key metabolic intermediate in sulfur amino acid metabolism, have been associ

Fred Van Leuven on The Theology of Aβ: Presenilins Giveth, and They Taketh Away

COMMENT The results reported by Raphaelle Pardossi-Piquard and colleagues are most interesting and also provocative. The implication is that the amyloid peptides (any or all) exert a physiologic function (which I have not seen demonstrated), and that this functio

Vincent Marchesi on Alteration of protein kinase C conformation in red blood cells: a potential marker for Alzheimer's disease but not for Parkinson's disease.

COMMENT I can't say that I agree with Paul Coleman's evaluation of this work. The method of analysis is quite convoluted, and it is not at all clear what is causing the difference in fluorescence intensity at particular wave lengths. It is very unlikely

Jeffery Vance on Search and Rescue in Parkin Fly Mutants—DA Neurons Are Lost, but Saved by GST

COMMENT Genes that affect the severity, duration, and course of Parkinson disease (PD) are just beginning to be explored. They are very important not only to understanding of the disease, but may provide the best opportunities to develop new treatments for PD. Af

Paul Coleman on Alteration of protein kinase C conformation in red blood cells: a potential marker for Alzheimer's disease but not for Parkinson's disease.

COMMENT Alzheimer’s Is Not a Brain Disease In this paper, Janoshazi et al. describe alterations of protein kinase C in erythrocytes of Alzheimer patients that distinguish them from erythrocytes of controls with “close to 100 percent” sensitivity and specificity.