Liu CW, Giasson BI, Lewis KA, Lee VM, DeMartino GN, Thomas PJ. A precipitating role for truncated alpha-synuclein and the proteasome in alpha-synuclein aggregation: implications for pathogenesis of Parkinson disease. J Biol Chem. 2005 Jun 17;280(24):22670-8. PubMed.

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  1. These are significant findings, suggesting a role for truncated alphaSyn in the pathogenesis of alphaSyn aggregation and disease, whereby incomplete degradation of alphaSyn may produce highly amyloidogenic fragments that contribute to the aggregation of full-length alphaSyn.

    View all comments by John Trojanowski

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