343764 RESULTS
RESEARCH MODELS Summary The first report of this transgenic line described two lines of mice that overexpress human PSEN1 with the M146L mutation, line 5.1 and line 6.2 (Duff et al., 1996). Line 5.1 has been more extensively characterized, especially in relation to the d
ALZPEDIA The sortilin-related receptor SORLA is an endocytic receptor that belongs to the vacuolar protein sorting 10 (VPS10) domain receptor family. SORLA binds to the amyloid precursor protein (APP). It functions as an intracellular sorting receptor as APP is be
COMMENT This necessary study supports, once again, the idea that microglia do not affect plaque formation in mouse models unless they are "activated" by drugs or immunotherapy or replaced by fresh macrophages. Whether this applies to humans, too, remain
COMMENT A very interesting finding, indeed! saak.ovsepian 0
COMMENT This study is most interesting. It gives strong evidence that manipulation of the innate immune system is an important therapeutic target for AD. The authors have shown that stimulation of innate immunity via TLR9 leads to reduction in both Aβ and tau-rel
COMMENT This is a very interesting concept. Almost three decades ago, we postulated the same hypothesis, based on histologic analysis of aged brains, demonstrating a blood brain barrier (BBB) breakdown and leakage of serum proteins in aged (but not young) human b
COMMENT The study by Hill et al. is a beautiful illustration of how structure predicts function. As Dr. Attwell has pointed out, a primary controversy here is a difficulty in identifying cells that reside at the junction between arterioles and capillaries. We rec
COMMENT This is an excellent summary to an already successful meeting. Kudos to Alzforum for showing us the art of writing a powerful summary. Batous_148501 0
COMMENT It is interesting, and appers logical, that NfL levels correlate better with intracellular than with extracellular pathology. saido 0
COMMENT I want to say "thanks" to scientists for developing tools that can identify people at greatest risk for the disease, and expedite their recruitment. This is great work. maryjsmith350_213486 0
COMMENT Following up on Jeanne's request for reminiscences, I recall that Allen's discussion with song and dance was entertaining and informative. Steve Younkin was there, too. I remember Dale showing a civil war picture and pointing to a gun and statin
COMMENT This study provides interesting new insights into the possible disease relevance of the accumulation of endolysosomal organelles within the dystropic axons that surround amyloid plaques. In a parallel effort, my group has recently identified a distinct JI
COMMENT The Lancet Commission report is an heroic achievement but it was rather selective in the risk factors that it reported and which formed the basis of the widely-cited claim that more than a third of dementia cases might be prevented if all the modifiable r
COMMENT Aducanumab may work because it reduces both insouble and soluble Abeta. However it may be incorrect to believe that the beneficial effect can only be manifest in early or prodromal disease because there is too much damage in more advanced cases. Instead i
COMMENT These findings were was novel to me, and show how the immune system is always surprising us. Systemic inflammation needs to be taken into account when considering cell-based therapy. There are multiple clinical trials planned for treatment of Parkinson’s
No filters selected
