344037 RESULTS
RESEARCH NEWS 2000-08-28 Research News A number of inherited neurodegenerative disorders (e.g., Huntingtons's disease and spinal and bulbar muscular atrophy) have been traced to the abnormal repetition of CAG sequences in the coding for particular proteins. These mutant prot
RESEARCH NEWS 2000-08-11 Research News A protein previously identified as a transporter of inorganic phosphate also transports glutamate into synaptic vesicles, according to a paper in today's Science by the University of California, San Francisco researcher Robert Edwards a
RESEARCH NEWS 2000-08-03 Research News Epidemiological studies have hinted strongly that nonsteroidal anti-inflammatory drugs (NSAIDs) might delay the progression of Alzheimer's disease. In the August 1 issue of the Journal of Neuroscience, evidence for this therapeutic opti
CONFERENCE COVERAGE 2000-08-02 Conference Coverage Reported by Mervyn Monteiro 2000 August 2. Presenilins and Lewy body pathology. Lippa et al (173) used α-synuclein immunoreactivity to determine the frequency of Lewy body (LB) occurrence in familial Alzheimer's disease (FAD) case
CONFERENCE COVERAGE 2000-07-28 Conference Coverage Reported by Benjamin Wolozin, Loyola University Medical Center www.meddean.luc.edu/lumen/DeptWebs/pharm/wolozin.htm Increasing attention has focused on the role of synucleins in neurodegeneration. α-synuclein was originally cloned by R
RESEARCH NEWS 2000-07-27 Research News Joseph F. Poduslo and colleagues at Mayo Clinic report in the August issue of Nature Biotechnology (pp. 868-872) on a technique for imaging Aβ deposits in living brain. The approach may allow an earlier diagnosis of Alzheimer's disease,
RESEARCH NEWS 2000-07-27 Research News Mice carrying the P301 mutation in tau, which causes human frontotemporal dementia, develop neurofibrillary pathology with features mimicking those of human tauopathies, report scientists at Mayo Clinic Jacksonville in the August issue of Na
INTERVIEWS 2000-07-26 Interviews ARF: Dr. Mayeux, your research has revealed several risk factors that are associated with AD. What do you think are the most important risk factors for the development of AD? RM: I think the most significant risk factors are genetic. The eviden
CONFERENCE COVERAGE 2000-07-26 Conference Coverage Reported by Paul Coleman Bradley T. Hyman and Paul D. Coleman, Chairs This symposium (held 10 July) covered the gamut of age-related evolution of brain function in AD from behavioral studies emphasizing mild cognitive impairment (MCI)
CONFERENCE COVERAGE 2000-07-26 Conference Coverage The relative paucity of presentations utilizing array technologies to study alterations of gene expression in Alzheimer's disease indicates that these powerful technologies are yet to be fully utilized in the study of AD. Three la
CONFERENCE COVERAGE 2000-07-26 Conference Coverage Mild cognitive impairment (MCI) has been defined as a clinical entity whose characteristics were reviewed by Ron Petersen. Persons with MCI have memory impairment beyond what would be expected for age, yet they are not demented. These
COMMENT The part of this report referring to Davies's earlier work (with Lu) on Pin1 and tau (Lu et al) is completely misleading. I quote: "Davies and colleagues previously have shown that Pin1 is present in Alzheimer's tangles, and that its bindin
CONFERENCE COVERAGE 2000-07-17 Conference Coverage There were a number of oral and poster presentations relating to BACE biology (abstracts 313, 504, 540, 1013, 1269 and 1272). As with the original descriptions of BACE, the reports presented at this meeting were in broad agreement. Und
CONFERENCE COVERAGE 2000-07-17 Conference Coverage The scientific highlight of the Prof. Henry Wisniewski memorial symposium (12 July) was an informative lecture about familial British dementia (FBD) delivered by Blas Frangione. His studies with the 34 amino acid long ABri protein (abs
CONFERENCE COVERAGE 2000-07-17 Conference Coverage Almost 12% (152) of the 1,307 abstracts presented at the 7th International Conference on Alzheimer’s Disease and related disorders made reference to presenilin (PS). For an overview of PS biology check out the webcast of Bruce Yankner’
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