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Progress in Neural Stem Cell Research

RESEARCH NEWS 2000-10-05 Research News Neural stem cells have been heralded as a potential therapy to rebuild injured and diseased brain tissue, but to achieve that vision, researchers must decipher the molecular signals that direct the cells to migrate through the brain and matu

Gene Therapy Rescues Neurons in Parkinson's Model

CONFERENCE COVERAGE 2000-10-05 Conference Coverage A two-gene therapy strategy prevents the death of dopamine neurons and preserves their function, according to a study by Jorg Schulz and colleagues at the University of Tubingen in Germany. The study was carried out in an MPTP mouse mo

β-Secretase 3D Structure

RESEARCH NEWS 2000-10-04 Research News Researchers announced a step forward in the rational design of drugs to inhibit β-secretase (also called memapsin 2 and BACE) with the publication in tomorrow's Science of the crystal structure of the enzyme locked in a complex with a n

A Sniffable Vaccine?

RESEARCH NEWS 2000-10-02 Research News A nasally administered vaccine of amyloid-β (Aβ) can significantly reduce the Aβ burden in the brains of transgenic mouse models of Alzheimer's disease, report Howard Weiner, Dennis Selkoe, and their Harvard colleagues in this month

Finally, a Mitochondrial Mutant

RESEARCH NEWS 2000-10-01 Research News A feat that has eluded researchers for some time-the creation of an animal model of human mitochondrial DNA (mtDNA) diseases-has finally been accomplished. Japanese researchers report that they have created mutant mice with a large-scale mtD

Another Role for the Prion: Evolutionary Key?

RESEARCH NEWS 2000-09-28 Research News The prion protein, so interesting to researchers of neurodegenerative disease for its novel capacity to cause disease through a change of conformation-and to transmit disease to other cells and organisms through its altered conformation-may

News Commentary on Nicastrin

RESEARCH NEWS 2000-09-15 Research News Through a nice piece of protein chemistry work, Yu and colleagues from Peter St. George Hyslop’s laboratory have shown that a novel protein, named nicastrin, associates with preseniln 1 and presenilin 2 (Yu et al., 2000). Surprisingly, this

William Klein on Normal Prion Protein Signals with Fyn

COMMENT Coupling of cellular prion proteins to Fyn is a real surprise, but maybe it shouldn't be. Fyn keeps popping up. Shirazi and Wood showed that tangle-bearing neurons in AD have a hefty overload of Fyn. Gloria Lee showed Fyn and tau co-localize. Gail Jo

Normal Prion Protein Signals with Fyn

RESEARCH NEWS 2000-09-14 Research News The intracellular protein Fyn-a suspect in the formation of neurofibrillary tangles because of its associations with tau protein-has now popped up in conjunction with prion diseases. Researchers in France report in tomorrow's Science th

Microarrays Probe Protein Interactions

RESEARCH NEWS 2000-09-08 Research News From today's Science: Researchers have built a microarray designed to study the interactions of thousands of proteins simultaneously, helping to uncover their function. As more and more genomes are sequenced, these protein microarrays w

Neurons Coaxed from Oligodendrocyte Precursors

RESEARCH NEWS 2000-09-08 Research News From today's issue of Science: The possibility of using stem cells from the brain to grow neural tissues has advanced a key step now that British scientists have coaxed certain nerve cells backwards in their development process to the s

Going Beyond the DNA

RESEARCH NEWS 2000-09-06 Research News High-throughput screening for proteins is now possible, according to report in this month's Nature Biotechnology. Researchers in England have designed an array, similar to DNA microarrays, that can screen for more than 18,000 proteins a

ApoE(ε)4 Brains Have to Work Harder

RESEARCH NEWS 2000-08-28 Research News The ε4 variant of the apolipoprotein-E (ApoE) gene has been shown to confer increased risk for Alzheimer's disease. Gary Small, Susan Bookheimer, and colleagues report in the New England Journal of Medicine that carriers of the ε4 allel

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